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Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction.
Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation ofExpand
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Dynamical Mechanism for Subcellular Alternans in Cardiac Myocytes
Rationale: Cardiac repolarization alternans is an arrhythmogenic rhythm disturbance, manifested in individual myocytes as a beat-to-beat alternation of action potential durations and intracellularExpand
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MinK-dependent internalization of the IKs potassium channel.
AIMS KCNQ1-MinK potassium channel complexes (4alpha:2beta stoichiometry) generate IKs, the slowly activating human cardiac ventricular repolarization current. The MinK ancillary subunit slows KCNQ1Expand
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Non-Linear Dynamics of Cardiac Alternans: Subcellular to Tissue-Level Mechanisms of Arrhythmia
Cardiac repolarization alternans is a rhythm disturbance of the heart in which rapid stimulation elicits a beat-to-beat alternation in the duration of action potentials and magnitude of intracellularExpand
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Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study.
Cardiac alternans is a dangerous rhythm disturbance of the heart, in which rapid stimulation elicits a beat-to-beat alternation in the action potential duration (APD) and calcium (Ca) transientExpand
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Fixed volume particle trace emission for the analysis of left atrial blood flow using 4D Flow MRI.
4D Flow MRI has been used to quantify normal and deranged left ventricular blood flow characteristics on the basis of functionally distinct flow components. However, the application of this techniqueExpand
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Genetic modifiers of the Kvβ2‐null phenotype in mice
Shaker‐type potassium (K+) channels are composed of pore‐forming α subunits associated with cytoplasmic β subunits. Kvβ2 is the predominant Kvβ subunit in the mammalian nervous system, but itsExpand
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Extra-cardiac manifestations of adult congenital heart disease.
Advancement in correction or palliation of congenital cardiac lesions has greatly improved the lifespan of congenital heart disease patients, resulting in a rapidly growing adult congenital heartExpand
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Catheter Ablation of Mid-Myocardial Ventricular Tachycardia by Simultaneous Unipolar Radiofrequency Ablation With Half-Normal Saline Irrigation.
A 54-year-old man with nonischemic cardiomyopathy and recurrent ventricular tachycardia (VT) refractory to quinidine, sotalol, mexiletine, and amiodarone; 4 prior ablation procedures; and bilateralExpand
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Mechanism and magnitude of bipolar electrogram directional sensitivity: characterizing underlying determinants of bipolar amplitude.
BACKGROUND The amplitude of bipolar electrograms (EGMs) is directionally sensitive, decreasing when measured from electrode pairs oriented oblique to a propagating wavefront. OBJECTIVE UseExpand
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