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Functional role of the N-terminal region of the Lon protease from Mycobacterium smegmatis.
Lon protease homologues contain a poorly conserved N-terminal region of variable length. To better understand the role of the N-terminal region of Lon in the complicated reaction cycle of…
The lon protease from Mycobacterium smegmatis: molecular cloning, sequence analysis, functional expression, and enzymatic characterization.
It is concluded that discrimination against nonsubstrate proteins is broadly conserved between Ec-Lon and Ms-lon, and a structural interaction between the peptidase and ATPase active sites of Ms- lon is observed.