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Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication.
A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal dose of cadmium chloride and results in a subsequent dose-dependent decrease in the liver and kidney burdens of Cadmium ion. Expand
Interleukin‐1β (IL‐1β) inhibition: a possible mechanism for the anti‐inflammatory potency of liposomally conjugated methotrexate formulations in arthritis
Joint inflammation in MTX treated rats was completely ameliorated by day 20 but the health and well being of the animals was compromised and the experiment terminated at this time‐point, demonstrating that both MTX‐EPC andMTX‐PEG liposomes have potential for development into therapeutic modalities for the treatment of inflammatory joint disease in man. Expand
Use of the Topliss scheme for the design of more effective chelating agents for cadmium decorporation.
Two compounds suggested by the Topliss scheme for pilot studies were much more effective than the parent compound (BGDTC), and of these the best one, sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate (MeOBGDTC) reduced kidney cadmium levels to 30% and liver cadmiam levels to 50% of those obtained with the parent compounds. Expand
Structural effects in the dithiocarbamate-enhanced biliary excretion of cadmium.
Those dithiocarbamates containing hydroxyl-bearing attached groups were found to be capable of causing the greatest enhancement of the cadmium content of the bile, which varied from 30-fold to over 2000-fold. Expand
Dithiocarbamate treatment of chronic cadmium intoxication in mice.
It was suggested that a Cd complexing agent of the dithiocarbamate class may have ultimate application in a provocative methodology to estimate body or organ Cd stores based upon the amount of Cd excreted following a standard dose of the chelator. Expand
Structure and function of the third maxillipeds of the banana prawn Penaeus merguiensis
The functions of the third maxilliped of Penaeus merguiensis de Man are described. It has a 6-segmented endopodite which is used in feeding, grooming and possible pheromone reception. In feeding,Expand
A comparison of diethyldithiocarbamate and EDTA as antidotes for acute cadmium intoxication.
For mice which have been given the cadmium equivalent of CdCl2 X 2 1/2H2O at a level of 10 mg/kg, diethyldithiocarbamate (DDTC) administration at 500 mg/kg leads to a higher survival rate than isExpand
Polarity and antidotal efficacy of dithiocarbamates in acute cadmium intoxication.
Structure-activity relationships among dithiocarbamate antidotes for acute cadmium chloride intoxication.
It has been possible to show that the accumulation of cadmium in the brain and kidney as well as the survival rates can be correlated with a numerical measure of the polarity of the groups R1 and R2, and a composite factor for antidotal efficacy which incorporates survival rate, brain Cadmium levels and kidney cadmiam levels is constructed. Expand
Effects of the mobilization of aged tissue cadmium by chelating agents.
An examination of the kidney and liver subsequent to the mobilization of aged cadmium deposits from them by the use of both dithiocarbamates and 1,2-dimercapto-1-propranolol (BAL) was carried out. NoExpand