• Publications
  • Influence
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.
N-Terminally truncated and pyroglutamate (pGlu) modified amyloid beta (Abeta) peptides are major constituents of amyloid deposits in sporadic and inherited Alzheimer's disease (AD). Formation of pGluExpand
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Single particle detection of Abeta aggregates associated with Alzheimer's disease.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Today, AD can be diagnosed with certainty only post-mortem, by histopathologic staining ofExpand
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Mirror image phage display--a method to generate D-peptide ligands for use in diagnostic or therapeutical applications.
Mirror image phage display is a straightforward approach to identify new potentially therapeutically active D-enantiomeric peptides. Such D-peptides are more resistant to proteolytic degradationExpand
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The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
BackgroundAmyloid fibrils such as Semen-Derived Enhancer of Viral Infection (SEVI) or amyloid-β-peptide (Aβ) enhance HIV-1 attachment and entry. Inhibitors destroying or converting those fibrils intoExpand
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Combination of computational prescreening and experimental library construction can accelerate enzyme optimization by directed evolution.
Chiral compounds can be produced efficiently by using biocatalysts. However, wild-type enzymes often do not meet the requirements of a production process, making optimization by rational design orExpand
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Combining independent drug classes into superior, synergistically acting hybrid molecules.
Increasing the potency of synthesized drugs has been a stepwise process accomplished by progressively modifying the chemical scaffold of a single parent lead compound. To date, there has been noExpand
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Directed Evolution of an Enantioselective Bacillus subtilis Lipase
Chiral compounds are of steadily increasing importance to the chemical industry, in particular for the production of pharmaceuticals. Where do these compounds come from? Apart from natural resources,Expand
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Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF: Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease
  • S. Funke
  • Medicine
  • International journal of Alzheimer's disease
  • 2 November 2011
The diagnosis of probable Alzheimer's disease (AD) can be established premortem based on clinical criteria like neuropsychological tests. Post mortem, specific neuropathological changes like amyloidExpand
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Multiplex‐PCR‐Based Recombination as a Novel High‐Fidelity Method for Directed Evolution
A new and convenient method for the in vitro recombination of single point mutations is presented. This method efficiently reduces the introduction of novel point mutations, which usually occurExpand
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Methods for the Specific Detection and Quantitation of Amyloid-β Oligomers in Cerebrospinal Fluid.
Protein misfolding and aggregation are fundamental features of the majority of neurodegenerative diseases, like Alzheimer's disease (AD), Parkinson's disease, frontotemporal dementia, and prionExpand
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