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Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects.
In the present study, we examined whether polymorphisms in the ATP-binding cassette (ABC) transporter genes, MDR1, MRP1 and MRP2, were associated with their respective mRNA expression levels inExpand
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Activation of NADPH oxidase in Alzheimer's disease brains.
The present study is the first to show that superoxide (O(-)(2)) forming NADPH oxidase is activated in Alzheimer's disease (AD) brains by demonstrating the marked translocation of the cytosolicExpand
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Mitochondrial dysfunction is involved in P2X7 receptor‐mediated neuronal cell death
J. Neurochem. (2012) 122, 1118–1128.
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Nonenzymatic glycation of transferrin: decrease of iron-binding capacity and increase of oxygen radical production.
The total iron-binding capacity (TIBC) and iron contents of diabetic rat serum, as well as the iron-binding capacity of glycated transferrin and oxygen radical production by the glycated proteinsExpand
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Monocarboxylate transporter mediates uptake of lovastatin acid in rat cultured mesangial cells.
To clarify the uptake mechanism(s) for statins, we examined whether monocarboxylate transporter (MCT) contributed to the uptake of lovastatin acid by rat cultured mesangial cells. Expression of mRNAsExpand
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Changes in caspase expression in Alzheimer's disease: comparison with development and aging.
Changes in caspase-2 and -3 protein levels in Alzheimer's disease (AD) brains were assessed in comparison with their expression in development and aging. The protein levels of caspase-2 and -3 wereExpand
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Purification, enzymatic properties, and active site environment of a novel manganese(III)-containing acid phosphatase.
A new manganese-containing acid phosphatase has been isolated and crystallized from sweet potato tubers. The pure enzyme contains one atom of manganese per Mr = 110,000 polypeptide and showsExpand
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Possible involvement of group I mGluRs in neuroprotective effect of theanine.
We investigated the molecular mechanism underlying the neuroprotective effect of theanine, a green tea component, using primary cultured rat cortical neurons, focusing on group I metabotropicExpand
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Aberrant accumulation of phospholipase C-delta in Alzheimer brains.
Since phosphoinositide-specific phospholipase C (PLC) is one of the key molecules in signal transduction, the authors assessed its involvement in Alzheimer's disease (AD). Immunostaining of aExpand
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