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Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver.
D-3-Aminoisobutyrate-pyruvate aminotransferase was purified 2000-fold from rat liver extract using heat treatment, ammonium sulfate fractionation, carboxylmethyl-Sepharose CL-6B, DEAE-SepharoseExpand
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The utilization of carnosine in rats fed on a histidine-free diet and its effect on the levels of tissue histidine and carnosine.
Carnosine can support the growth of rats fed on a histidine-free diet. Rats fed on the histidine-free diet lost weight rapidly for a few days, then remained at a relatively constant weight for 2Expand
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Submitochondrial localization of rat liver beta-alanine-oxoglutarate aminotransferase.
beta-Alanine-oxoglutarate aminotransferase from rat liver was mainly distributed in the mitochondrial fraction, while beta-ureidopropionase, the last one of uracil-metabolizing enzymes toExpand
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Evaluation of interconversion between (R)- and (S)-enantiomers of β-aminoisobutyrate
Abstract The conversion of (R)- to (S)-β-aminoisobutyrate was observed in the presence of d -3-aminoisobutyrate-pyruvate aminotransferase, aminobutyrate aminotransferase, pyruvate and l -glutamate.Expand
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Purification and properties of β-ureidopropionase from the rat liver
β-Ureidopropionase was purified 1000-fold over the initial rat liver extract, using heat treatment, ammonium sulfate fractionation, CM-Sepharose CL-6B, DEAE-Sepharose CL-6B, hydroxyapatite andExpand
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Carnosine as a histidine source: transport and hydrolysis of exogeneous carnosine by rat intestine.
Transport and metabolism of L-carnosine (beta-alanyl-L-histidine) were studied in rat small intestine. Carnosine administered orally was found in rat serum as well as small intestine and liver,Expand
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Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase activity.
Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase was investigated. It was found that the purified enzyme contains 2 mol flavin per molecule, which consists of equalExpand
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Effect of pyridoxine deficiency and prednisolone on beta-alanine-oxoglutarate aminotransferase and D-3-aminoisobutyrate aminotransferase in rat liver and kidney.
beta-Alanine-oxoglutarate aminotransferase (beta-Ala-TI) was found to be distributed mainly in liver, brain, kidney, and testis (decreasing order of enzyme activity in the rat). D-3-AminoisobutyrateExpand
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The level of beta-alanine aminotransferase activity in regenerating and differentiating rat liver.
beta-Alanine aminotransferase from rat liver was purified to electrophoretic homogeneity. The immunological and kinetic properties of this enzyme were similar to those of the enzyme from rat brain.Expand
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Increased β‐aminoisobutyric acid in rat liver with 6‐azauracil and its enantiomer
When 6‐azauracil was subcutaneously injected, β‐aminoisobutyric acid and β‐alanine contents were increased 22 and 61‐fold, respectively, in rat liver. Incorporation of [methyl‐14Cithymine intoExpand
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