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Total synthesis of RK-397.
An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly… Expand
Stereoselective conjugate addition reactions using in situ metallated terminal alkynes and the development of novel chiral P,N-ligands
- S. Fujimori, T. Knoepfel, Pablo Zarotti, T. Ichikawa, Dean Boyall, E. Carreira
- 13 September 2007
In this account, new methods for the catalytic and stereoselective conjugate addition of terminal alkynes are described. Our laboratories have disclosed asymmetric addition reactions to aldehydes a...
Diastereoselective Aldol Addition Reactions of a Chiral Methyl Ketone Trichlorosilyl Enolate under Lewis Base Catalysis
The trichlorosilyl enolate of a chiral methyl ketone bearing an oxygen substituent (OTBS) on the β-position undergoes highly diastereoselective aldol addition to a variety of achiral aldehydes in… Expand
Lewis base catalyzed aldol additions of chiral trichlorosilyl enolates and silyl enol ethers.
- S. Denmark, S. Fujimori, S. M. Pham
- Chemistry, Medicine
- The Journal of organic chemistry
- 23 December 2005
[structures: see text] The consequences of double diastereodifferentiation in chiral Lewis base catalyzed aldol additions using chiral enoxysilanes derived from lactate, 3-hydroxyisobutyrate, and… Expand
The effects of a remote stereogenic center in the Lewis base catalyzed aldol additions of chiral trichlorosilyl enolates.
Chiral trichlorosilyl enolates bearing a remote stereogenic center were employed in the phosphoramide-catalyzed aldol reaction. The additions of the methyl ketone enolates proceeded with only… Expand
Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II.
- H. Tosa, Munekazu Iinuma, +6 authors S. Fujimori
- Biology, Medicine
- Biological & pharmaceutical bulletin
- 15 June 1998
In a series of searches for DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification… Expand
Diastereoselective aldol additions of chiral beta-hydroxy ethyl ketone enolates catalyzed by Lewis bases.
The trichlorosilyl enolates derived from chiral ethyl ketones bearing a beta-hydroxyl group and an alpha-stereogenic center were employed in the phosphoramide-catalyzed aldol reaction. The addition… Expand
Catalytic Enantioselective Aldol Additions with Chiral Lewis Bases
Preparation of hexakis(4-Bromophenyl)benzene (HBB) [1,1':2',1''-Terphenyl, 4,4''-dibromo-3',4',5',6'-tetrakis(4-Bromophenyl)-]
Enantio- and meso-oligodeoxyribonucleotides.
- S. Fujimori, N. Iwanami, K. Shudo, Y. Hashimoto
- Chemistry, Medicine
- Nucleic acids symposium series
As sugar-modified oligodeoxyribonucleotides, L-homooligomers (L-dA12 and L-dT12) and a L/D-alternative oligomer ((L-dA-D-dA)6) were synthesized. These oligomers were quite resistant towards… Expand