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Extensive Cortical Rewiring after Brain Injury
The results suggest that M1 injury results in axonal sprouting near the ischemic injury and the establishment of novel connections within a distant target, and support the hypothesis that, after a cortical injury, such as occurs after stroke, cortical areas distant from the injury undergo major neuroanatomical reorganization. Expand
Role of adaptive plasticity in recovery of function after damage to motor cortex
These findings have strong clinical relevance as it has recently been shown that after injury to the motor cortex, as might occur in stroke, post‐injury behavioral experience may play an adaptive role in modifying the functional organization of the remaining, intact cortical tissue. Expand
Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery.
It is suggested that neurophysiologic reorganization of remote cortical areas occurs in response to cortical injury and that the greater the damage to reciprocal intracortical pathways, the great the plasticity in intact areas. Expand
Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates
Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury. Expand
Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey.
Data suggest that, at least in squirrel monkeys, descending output from M1 and dorsal and ventral premotor cortices is not necessary for SMA representations to be maintained and that SMA motor output maps undergo delayed increases in representational area after damage to other motor areas. Expand
Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.
The results suggest that after a lesion in the M1 DFL, the induction of representational plasticity in PMv, as evaluated using intracortical microstimulation, is related more to the size of the lesion than to the disruption of its intrACortical connections. Expand
Ipsilateral connections of the ventral premotor cortex in a new world primate
The present study describes the pattern of connections of the ventral premotor cortex (PMv) with various cortical regions of the ipsilateral hemisphere in adult squirrel monkeys. Particularly, we 1)Expand
Neuronal HIF-1α Protein and VEGFR-2 Immunoreactivity in Functionally Related Motor Areas following a Focal M1 Infarct
While remote areas undergo a molecular response to the infarct, it is hypothesized that there is a delay in the initiation of the response, which ultimately may increase the ‘window of opportunity’ for neuroprotective interventions in the intact cortex. Expand
Somatosensory and motor representations in cerebral cortex of a primitive mammal (Monodelphis domestica): A window into the early evolution of sensorimotor cortex
Examination of the cytoarchitecture in this cortical region (reminiscent of typical mammalian somatosensory cortex) and the high levels of stimulation needed for vibrissae movement suggest that the parietal neocortex of Monodelphis is representative of a primitive sensorimotor condition. Expand
An animal model of capsular infarct: Endothelin-1 injections in the rat
The present model of white matter infarct should be valuable in examining the underlying mechanisms of subcortical ischemic stroke and to evaluate potential therapeutic interventions. Expand