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Gene expression profiling predicts clinical outcome of breast cancer
TLDR
DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
The Consensus Molecular Subtypes of Colorectal Cancer
TLDR
An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.
TLDR
A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.
A gene-expression signature as a predictor of survival in breast cancer.
TLDR
The gene-expression profile studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria.
Genetics of gene expression surveyed in maize, mouse and man
Treating messenger RNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been pursued in gene-specific ways. Transcript abundances
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles.
TLDR
Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response and global transcript analysis reflects biological responses associated with the activation and perturbation of signalTransduction pathways.
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
TLDR
The isolation of a complementary DNA segment that detects a chromosomal segment having the properties of the gene at this locus is described, which is expressed in many tumour types, but no RNA transcript has been found in retinoblastomas and osteosarcomas.
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
TLDR
It is found that 60-mer oligonucleotides reliably detect transcript ratios at one copy per cell in complex biological samples, and that ink-jet arrays are compatible with several different sample amplification and labeling techniques.
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