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Clinical efficacy of cell culture–derived and egg‐derived inactivated subunit influenza vaccines in healthy adults.
Both CCIV and TIV were effective in preventing influenza caused by vaccine-like and by all circulating influenza virus strains, were well tolerated, and had good safety profiles. Expand
Dose-related effects of smallpox vaccine.
The development of vesicular skin lesions after vaccination correlates with the induction of the antibody and T-cell responses that are considered essential for clearing vaccinia virus infections. Expand
Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles.
MVA62 was well tolerated and elicited different patterns of T cell and Ab responses when administered alone or in combination with the JS7 DNA vaccine. Expand
Clinical responses to undiluted and diluted smallpox vaccine.
When given by a bifurcated needle, vaccinia virus vaccine can be diluted to a titer as low as 10(7.0) pfu per milliliter and induce local viral replication and vesicle formation in more than 97 percent of persons. Expand
Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues.
The intranasal monovalent adjuvanted Norwalk VLP vaccine was well tolerated and highly immunogenic and is a candidate for additional study. Expand
Improved Assay To Detect Neutralizing Antibody following Vaccination with Diluted or Undiluted Vaccinia (Dryvax) Vaccine
The more sensitive, specific, and reproducible plaque neutralization assay for the detection of antibody to Vaccinia virus is the method using a 15-h-incubation time and freshly sonicated vaccinia virus. Expand
Glycosylations in the Globular Head of the Hemagglutinin Protein Modulate the Virulence and Antigenic Properties of the H1N1 Influenza Viruses
Hemagglutinin glycosylations modulate the virulence and antigenicity of H1N1 influenza viruses. Hitting Flu Head-On Viruses and the immune system are engaged in a battle royale—each constantly tryingExpand
Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus
It is demonstrated that vaccination with the 2009 pandemic H1N1 vaccine elicits 1918 virus cross-protective antibodies in mice and humans, and that vaccination or passive transfer of human-positive sera reduced morbidity and conferred full protection from lethal challenge with the 1918 virus in mice. Expand
Response to smallpox vaccine in persons immunized in the distant past.
Previously vaccinated persons can be successfully revaccinated with diluted (<or=1:10) smallpox vaccine, and fewer adverse reactions were observed in this study of non-naive participants when compared with events in vaccinia-NAive participants, which may be due to immunologic memory. Expand
AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial.
AS03-adjuvanted inactivated trivalent influenza vaccine (TIV) has a higher efficacy for prevention of some subtypes of influenza than does a non-adJuvanted TIV, and future influenza vaccine studies in elderly people should be based on subtype or lineage-specific endpoints. Expand