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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population. Expand
Dishevelled controls cell polarity during Xenopus gastrulation
It is shown that polarized cell behaviour is essential for convergent extension and is controlled by vertebrate Dishevelled, suggesting that a vertebrate equivalent of the Drosophila planar cell polarity signalling cascade may be required for normal gastrulation. Expand
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
In vivo imaging is shown to show the presence of high-shear, vortical flow at two key stages in the developing heart, and predict flow-induced forces much greater than might have been expected for micro-scale structures at low Reynolds numbers. Expand
Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart
The directionality of local blood flow in the zebrafish embryonic heart is essential for proper heart valve formation.
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis
It is demonstrated that the Dsh protein is post‐translationally modified at the dorsal side of the embryo: timing and position of this regulation suggests a role of Dsh in dorsal–ventral patterning in Xenopus. Expand
Structure and Emergence of Specific Olfactory Glomeruli in the Mouse
Three-dimensional reconstructions of OSNs constructed by gene targeting novel strains of mice in which either all OSNs or those that express a specific OR gene also produce green fluorescent protein (GFP) or a fusion of tau with GFP show a high degree of morphological variability of mature glomeruli receiving axonal input from OR-expressing OSNs and of the pathways taken by the axons to thoseglomeruli. Expand
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
The results demonstrate that Eph-family receptor tyrosine kinases and their transmembrane ligands are involved in interactions between neural crest and sclerotomal cells, mediating an inhibitory activity necessary to constrain neural precursors to specific territories in the developing nervous system. Expand
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.
The normal expression of Xenopus laevis Wnt-5A is characterized, and the consequences of misexpression of this putative signalling factor are investigated, consistent with Xwnt- 5A having the potential activity of modifying the morphogenetic movements of tissues. Expand
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
A high degree of conservation between Dvl function in mammalian convergent extension and the PCP pathway in fly is demonstrated, and in the neuroepithelium of neurulating embryos, Dvl2 shows DEP domain-dependent membrane localization, a pre-requisite for its involvement in convergent extensions. Expand
Convergent extension: the molecular control of polarized cell movement during embryonic development.
Focusing on frogs and fish, the different cellular mechanisms and the well-conserved signaling pathways that underlie this process of lengthening and narrowing of a field of cells are reviewed. Expand