• Publications
  • Influence
Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.
TLDR
Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk. Expand
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.
TLDR
It is shown that polycystic ovaries, as defined by pelvic ultrasound, are very common in anovulatory women and are not necessarily associated with hirsutism or a raised serum luteinising hormone concentration. Expand
Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17.
TLDR
Variation in the A2 allele of the CYP17 gene is a significant factor modifying the expression of PCO/MPB in families where it has been demonstrated to segregate as a single gene disorder, but it is excluded as the primary genetic defect. Expand
POLYCYSTIC OVARY SYNDROME: A CHANGING PERSPECTIVE
  • S. Franks
  • Biology, Medicine
  • Clinical endocrinology
  • 1 July 1989
TLDR
The article reports clinical and endocrine features in 300 women with PCOS, and discuses its etiology and the mechanism of anovulation. Expand
Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome.
TLDR
Moderate weight loss during long-term calorie restriction is associated with a marked clinical improvement which reflects the reduction in insulin concentrations and reciprocal changes in SHBG, and may be consequent upon an increase in insulin sensitivity which, directly or indirectly, affects ovarian function. Expand
POLYCYSTIC OVARIES—A COMMON FINDING IN NORMAL WOMEN
TLDR
The prevalence of polycystic ovaries (PCO) in normal women of reproductive age was determined by pelvic ultrasound scanning of 257 volunteers who considered themselves to be normal and who had not sought treatment for menstrual disturbances, infertility, or hirsutism, which suggest that PCO in women who consider themselves toBe normal is part of the same clinical spectrum as the classic Stein-Leventhal syndrome. Expand
MULTIFOLLICULAR OVARIES: CLINICAL AND ENDOCRINE FEATURES AND RESPONSE TO PULSATILE GONADOTROPIN RELEASING HORMONE
TLDR
In MFO ovarian morphology reverted to normal in ovulatory cycles, whereas in PCO the polycystic pattern persisted despite the presence of a dominant follicle, suggesting MFO may represent a normal ovarian response to weight-related hypothalamic disturbance of gonadotropin control. Expand
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
TLDR
A meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores, identifies three novel loci that likely represent age-related differences in strength of the associations with bodymass index. Expand
Follicle dynamics and anovulation in polycystic ovary syndrome.
TLDR
Significant abnormalities in the very earliest stages of folliculogenesis may be the root cause of anovulation in PCOS. Expand
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