Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk.Expand
It is shown that polycystic ovaries, as defined by pelvic ultrasound, are very common in anovulatory women and are not necessarily associated with hirsutism or a raised serum luteinising hormone concentration.Expand
Variation in the A2 allele of the CYP17 gene is a significant factor modifying the expression of PCO/MPB in families where it has been demonstrated to segregate as a single gene disorder, but it is excluded as the primary genetic defect.Expand
Moderate weight loss during long-term calorie restriction is associated with a marked clinical improvement which reflects the reduction in insulin concentrations and reciprocal changes in SHBG, and may be consequent upon an increase in insulin sensitivity which, directly or indirectly, affects ovarian function.Expand
The prevalence of polycystic ovaries (PCO) in normal women of reproductive age was determined by pelvic ultrasound scanning of 257 volunteers who considered themselves to be normal and who had not sought treatment for menstrual disturbances, infertility, or hirsutism, which suggest that PCO in women who consider themselves toBe normal is part of the same clinical spectrum as the classic Stein-Leventhal syndrome.Expand
In MFO ovarian morphology reverted to normal in ovulatory cycles, whereas in PCO the polycystic pattern persisted despite the presence of a dominant follicle, suggesting MFO may represent a normal ovarian response to weight-related hypothalamic disturbance of gonadotropin control.Expand
A meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores, identifies three novel loci that likely represent age-related differences in strength of the associations with bodymass index.Expand