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Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.
TLDR
It is suggested that estradiol may play a role in enhancement of Leydig cell tumors in the rat, and that peroxisome proliferators may induce tumors via a non-LH type mechanism.
Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and
TLDR
Data show that PPARa is the most likely target of PFOA and PFOS, although PPARg is also activated to some extent, and compared to naturally occurring long-chain fatty acids, these perfluorinated fatty acid analogs were more selective and less potent in their activation of the NRs.
Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens.
TLDR
5 of the six test substances were identified as endocrine-active substances consistent with their known/proposed mechanism(s) of action and increased relative liver weight, illustrating that the ability to identify EACs using the intact male assay will be equivalent regardless of the route of compound administration.
Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha,
TLDR
Data show that PPARalpha is the most likely target of PFOA and PFOS, although PPARgamma is also activated to some extent, compared to naturally occurring long-chain fatty acids, which were more selective and less potent in their activation of the NRs.
Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha.
TLDR
Current and recently published work exploring immunomodulation by PFOA and PFOS are described, and potential PPARalpha independence indicates that future research must explore mechanisms of action of these compounds, including PPAR alpha-dependent and -independent pathways.
90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17 beta-estradiol.
TLDR
This 90-day/one-generation reproduction study with 17 beta-estradiol was designed to set dose levels for future multigenerational reproduction and combined chronic toxicity/oncogenicity studies, and to provide benchmark data for a risk assessment for chemicals with estrogen-like activities.
Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate.
TLDR
In rats and mice, immune-related changes occurred only at doses causing significant and profound systemic toxicity and stress, while in mice, no immune- related changes occurred in rats, even at doses caused by systemic toxicity.
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