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Current source density analysis of the hippocampal theta rhythm: associated sustained potentials and candidate synaptic generators
Single-electrode depth profiles of the hippocampal EEG were made in urethane-anesthetized rats and rats trained in an alternating running/drinking task. Current source density (CSD) was computed from…
Do septal neurons pace the hippocampal theta rhythm?
Four models of the septo-hippocampal connections involved in theta rhythm production are reviewed as the precise roles of these projections are discussed, and in the final, consolidated model both cholinergic and GABAergic septal projection cells fire in rhythmic bursts that entrain hippocampal interneurons.
Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats
Differences in the firing of hippocampus and dentate gyrus of rats during walking and urethane anesthesia represent some of the differences in cellular mechanisms distinguishing two kinds of hippocampal theta rhythm.
Intracellular recordings from medial septal neurons during hippocampal theta rhythm
The phasic inhibition of ”cholinergic” MS/DB neurons by ”GABAergic’ MS/ DB neurons, followed by a rebound of their firing, is proposed as a mechanism contributing to recruitment of the wholeMS/DB neuronal population into the synchronized rhythmic bursting pattern of activity that underlies the occurrence of the hippocampal theta rhythm.
Action potentials and relations to the theta rhythm of medial septal neurons in vivo
The results suggest that generation of theta rhythm requires a background of excitatory influences on the hippocampus in combination with the phasic disinhibitory action mediated by the GABAergic MS-DB projection.
Localization and anatomical identification of theta and complex spike cells in dorsal hippocampal formation of rats
The class of projection cells and the class of nontheta cells have a very large overlap, and that the classes of interneurons and theclass of theta cells have an extremely large overlap.
Muscarinic Blockade Slows and Degrades the Location-Specific Firing of Hippocampal Pyramidal Cells
It is demonstrated that acetylcholine enhances positional firing patterns in the hippocampus, which weakens the positional firing of most place cells and therefore renders them less useful for precise representation of the environment.
Electrophysiological characteristics of hippocampal complex-spike cells and theta cells
Stimulating electrodes were chronically implanted in the ventral hippocampal commissure and the entorhinal cortex or angular bundle of rats and the data is consistent with most of them being inhibitory interneurons, but this is not established.
Two populations of rhythmically bursting neurons in rat medial septum are revealed by atropine.
Evaluating the mechanism(s) of action of systemic antimuscarinic drugs in eliminating the theta rhythm in rats suggests that the loss of rhythmic activity in the group of atropine-sensitive septal cells is sufficient for the elimination of the theTA rhythm.
The Effects on Place Cells of Local Scopolamine Dialysis Are Mimicked by a Mixture of Two Specific Muscarinic Antagonists
- E. Brazhnik, R. Borgnis, R. Muller, S. Fox
- Chemistry, MedicineThe Journal of Neuroscience
- 20 October 2004
The effects of scopolamine on place cells likely result from a combination of blockade of postsynaptic m1 receptors, leading to reduced excitability, with blockade of presynaptic m2 and m4 receptors, lead to increased out-of-field firing.