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The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases.
The results suggest that PI 3-kinase and the small GTPases, Ras, RhoA and Cdc42 may be part of a common functional pathway involved in Fliih-mediated cytoskeletal regulation. Expand
Fliih, a Gelsolin-Related Cytoskeletal Regulator Essential for Early Mammalian Embryonic Development
A transgenic mouse carrying the complete human FLII gene is constructed and shown that the FLII transgene is capable of rescuing the embryonic lethality of the homozygous targeted Fliih mutation. Expand
The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31.
Analysis of human ESTs showed that there are two different but closely related human transcripts, one of which corresponds to PIN1, and PCR on DNA from hamster/human somatic cell hybrids retaining chromosomes 1 or 19 was used to map the human PIN1 gene to chromosome 19, and PIN1L, a closely related gene, to chromosome 1. Expand
Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.
The Drosophila melanogaster flightless-I gene is involved in cellularization processes in early embryogenesis and in the structural organization of indirect flight muscle, giving indications of gelsolin gene family evolution. Expand
Fliih, the Murine Homologue of the Drosophila melanogaster flightless I Gene: Nucleotide Sequence, Chromosomal Mapping and Overlap With Llglh
The sequence of the genomic DNA in this area, combined with cDNA sequences, establishes that the 3′ ends of the FIiih and Llglh transcripts overlap, and the overlap region contains poIyA signals for both genes and is conserved between human and mouse. Expand
Australian population data for the twenty Promega PowerPlex 21 short tandem repeat loci
This paper describes the analysis of population data typed using the Promega PowerPlex 21 multiplex for the three major sub populations within Australia. Samples from 1427 declared AustralianExpand
The flightless I protein
The Drosophila melanogaster flightless I (fliI ) gene encodes a 1,256 amino acid protein with a predicted molecular mass of 143,672 Da (Campbell et al., 1993). It has highly conserved homologues inExpand