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Mechanisms of actions of inhaled anesthetics.
“Suffering so great as I underwent cannot be expressed in words . . . but the blank whirlwind of emotion, the horror of great darkness, and the sense of desertion by God and man, which swept throughExpand
Herbal Medicines and Perioperative Care
Herbal Medicines and Perioperative Care THE article by Lee et al. is an important addition to the anesthesia literature. Several survey studies have documented the widespread use of herbal productsExpand
Clinical and Molecular Pharmacology of Etomidate
This review focuses on the unique clinical and molecular pharmacologic features of etomidate. Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the most favorableExpand
Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo.
The results suggest that the inhibitory effect of long chain alkanols may be mediated by a discrete site on nicotinic acetylcholine receptors, whereas there is no evidence that a protein site is involved in the excitatory mechanism of short chainAlkanols, and it seems more likely that short chain al Kanols may have a nonspecific site of action. Expand
An Allosteric Coagonist Model for Propofol Effects on &agr;1&bgr;2&ggr;2L &ggr;-Aminobutyric Acid Type A Receptors
The hypothesis that propofol, like etomidate, acts at GABAA receptor sites mediating both GABA modulation and direct activation is supported. Expand
Classic Benzodiazepines Modulate the Open–Close Equilibrium in &agr;1&bgr;2&ggr;2L &ggr;-Aminobutyric Acid Type A Receptors
Independent of orthosteric site occupancy, classic benzodiazepines modulate the gating equilibrium in &agr;1&bgr;2&ggr;2L GABAA receptors and are therefore allosteric coagonists. Expand
Correlating the clinical actions and molecular mechanisms of general anesthetics
Understanding the mechanisms underlying the therapeutic and toxic actions of general anesthetics helps to reframe the ‘art’ of anesthesia into more of a ‘science’ and enhances efforts to develop new drugs with improved clinical utility. Expand
A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport
Two-electrode studies indicate that EGFP-[M137]hNaPi-IIc is nonelectrogenic but displayed a significant phosphate-independent inward-rectified sodium current, which appears to be insensitive to phosphonoformic acid and thus may uncouple sodium-phosphate cotransport in human NaPi- IIc. Expand
Coupled and Uncoupled Gating and Desensitization Effects by Pore Domain Mutations in GABAA Receptors
Results indicate that both α1(L264T) and α1 (S270I) mutations increase the gating efficacy of receptors by slowing channel closing, which accounts for nearly all of the similar changes that they produce in macrocurrent dynamics. Expand
A discrete site for general anesthetics on a postsynaptic receptor.
It is found that specific mutations in the acetylcholine receptor pore-forming M2 domains enhance the sensitivity of the receptor to the general anesthetics isoflurane, hexanol, and octanol, suggesting that these agents act by binding directly to a discrete protein site at or near these residues. Expand