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Clinical and pathological features of pachyonychia congenita.
Analysis of clinical, pathological, and genetic data from the literature and two research registries reveal that >97% of PC cases exhibit fingernail and toenail thickening, and painful plantar keratoderma. Expand
Proliferation, Apoptosis, and Survivin Expression in Keratinocytic Neoplasms and Hyperplasias
The dysregulation of apoptosis occurs in many cutaneous disease states. Several apoptosis inhibitors have been shown elevated in neoplasms and in some inflammatory conditions, but their relation toExpand
Lentigo Maligna/Lentigo Maligna Melanoma: Current State of Diagnosis and Treatment
Adequate treatment of LM requires a comprehensive knowledge of the diagnostic features, histopathology, and treatment options, and surgical modalities with meticulous evaluation of tissue margins appears to offer the lowest rates of disease recurrence. Expand
Preservation of RNA for Functional Genomic Studies: A Multidisciplinary Tumor Bank Protocol
It is concluded that tissues treated with RNAlater before routine processing are indistinguishable histologically and immunohistochemically from tissues processed in routine fashion and that the RNA isolated from these tissues is of high quality and can be used for molecular studies. Expand
CD117, CK20, TTF-1, and DNA topoisomerase II-alpha antigen expression in small cell tumors.
CK20 and TTF-1 appear to be reliable in distinguishing MCC from SCLC, and the high PI seen in MCCs suggests a role for topoisomerase II inhibitors in their treatment. Expand
N-Acetylcysteine Protects Melanocytes against Oxidative Stress/Damage and Delays Onset of Ultraviolet-Induced Melanoma in Mice
The data highlight the potential importance of oxidative stress in the pathogenesis of melanoma and suggest that NAC may be useful as a chemopreventive agent. Expand
Digital Dermoscopic Monitoring of Atypical Nevi in Patients at Risk for Melanoma
Most clinically atypical melanocytic nevi are stable over time, and lesions exhibiting dermoscopic changes are most likely to be dysplastic nevi. Expand
Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.
Results indicate that despite a paradoxical negative effect on tumor formation, survivin expression prevents papilloma regression and promotes conversion to SCC, consistent with its expression in most skin cancers and their precursors. Expand
CD117, CK20, TTF‐1, and DNA topoisomerase II‐α antigen expression in small cell tumors
This work has shown that identifying merkel cell carcinoma metastatic to the skin, small cell lung carcinoma (SCLC), and atypical basal cell carcinomas (BCC) can be problematic in some cases. Expand
Effects of trastuzumab on epidermal growth factor receptor‐dependent and ‐independent human colon cancer cells
Predicting clinical responsiveness of human colon cancer cells to anti‐HER‐2 and anti‐EGFR therapy may require demonstration of EGFR tyrosine kinase dependency of the cells. Expand