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Altered clot kinetics in patients with non-alcoholic fatty liver disease.
TLDR
Patients with NAFLD have disturbances in ex-vivo clot kinetics including increased clot strength and clots that are more resistant to thrombin-stimulated lysis, which is linked to increased risk for cardiovascular events. Expand
Comparison of Active Venom Components between Eastern Brown Snakes Collected from South Australia and Queensland
TLDR
It is concluded that geographic differentiation of the Eastern brown snakes results in significant differences venom potency. Expand
Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms.
TLDR
TSPI was found to be a broad spectrum inhibitor with most potent inhibitory activity observed against plasma kallikrein that corresponded to a K(i) of 0.057 ± 0.019 nM. Expand
Comparison of Textilinin-1 with Aprotinin as Serine Protease Inhibitors and as Antifibrinolytic Agents
TLDR
From data, textilinin-1 appears to be a more specific plasmin inhibitor than aprotinin but aProtinin inhibits clot lysis to a greater extent. Expand
Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids.
TLDR
The identification and detailed comparative analysis of the cDNA transcripts coding for the mature natriuretic peptide from a total of nine Australian elapid snake species represent a significant resource for understanding the role of various natriurtic peptides isoforms during the envenomation process by Australian elapseid snakes. Expand
Textilinin‐1, an alternative anti‐bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss
TLDR
Textilinin‐1, a serine protease inhibitor from Pseudonaja textilis venom with sequence relatedness to aProtinin, is a potent but reversible plasmin inhibitor and has a narrower range of protease inhibition compared to aprotinin. Expand
Resistance of porcine blood clots to lysis relates to poor activation of porcine plasminogen by tissue plasminogen activator
TLDR
Results suggest caution in using the pig as an experimental model when studying the effects of various agents on fibrinolysis, and offer the resistance of porcine plasminogen to activation by t-PA as an explanation. Expand
Cloning and functional expression of venom prothrombin activator protease from Pseudonaja textilis with whole blood procoagulant activity
TLDR
This study identified the complete cDNA sequence of a factor Xa‐like protease from P. textilis and demonstrated for the first time the expression of a recombinant form of P.textilis protease capable of blood coagulation. Expand
Use of Defined Estrone Glucuronide–Hen Egg White Lysozyme Conjugates as Signal Generators in Homogeneous Enzyme Immunoassays for Urinary Estrone Glucuronide
TLDR
There was no advantage gained in separating E1 and E3, but higher substituted conjugates such as E5 need removal for best assay performance, and the menstrual cycle pattern was similar for the three signal generators, but the E1G excretion rates yielded by E5 as the signal generator were only 60% of the reference values. Expand
The Regulatory Environment for Cell Therapies in Australia – an Opportunity to Expedite Clinical Development
Early phase clinical development of cell based therapies in Australia can benefit from an abbreviated regulatory approval pathway, requiring limited resource burden relative to a European clinicalExpand
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