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The Synthetic Cannabinoid R(+)WIN 55,212-2 Inhibits the Interleukin-1 Signaling Pathway in Human Astrocytes in a Cannabinoid Receptor-independent Manner*
- Niamh Curran, B. Griffin, D. O’Toole, K. Brady, S. Fitzgerald, P. Moynagh
- BiologyJournal of Biological Chemistry
- 28 October 2005
Electrophoretic mobility shift and chromatin immunoprecipitation assays showed that R(+)WIN 55,212-2 does not regulate the IL-1-induced nuclear translocation of NFκB or the ability of the latter to bind to promoters regulating expression of ICAM-1 and IL-8.
Molecular Analysis of the tagF Gene, Encoding CDP-Glycerol:Poly(glycerophosphate) Glycerophosphotransferase of Staphylococcus epidermidis ATCC 14990
The cloned S. epidermidis tagF gene encodes a functional CDP-glycerol:poly(glyceroph phosphate) glycerophosphotransferase, which suggests that the tagf gene is essential and that the TagF and other enzymes involved in teichoic acid biosynthesis could be targets for new antistaphylococcal drugs.
Tumour-necrosis-factor-receptor-associated factor 6, NF-kappaB-inducing kinase and IkappaB kinases mediate IgE isotype switching in response to CD40.
The results suggest that CD40 employs TRAF-6, which presumably recruits NIK, which in turn employs IKK-1/IKK-2 to activate NF-kappaB and the Cepsilon promoter, the prologue to IgE switching, which defines a crucially important pathway in the generation of allergic states.
CD40 employs p38 MAP kinase in IgE isotype switching.
- K. Brady, S. Fitzgerald, S. Ingvarsson, C. Borrebaeck, P. Moynagh
- BiologyBiochemical and biophysical research…
- 23 November 2001
It is suggested that p38 MAPK is crucially important in mediating CD40 activation of NF kappa B which acts to induce C epsilon germline transcripts, ultimately facilitating IgE switching.
Tumour-necrosis-factor-receptor-associated factor 6 , NF-κ B-inducing kinase and I κ B kinases mediate IgE isotype switching in response to CD 40
The present study explores the uncharacterized signalling pathways employed by CD40 in activating NF-κB by the overexpression of genes encoding wildtype and dominant-negative forms of the signalling components tumour-necrosis-factor-receptor-associated factor 6 (TRAF-6), NF-β-inducing kinase, NIK, IκB kinase (IKK)-1 and IKK-2 in the BJAB B-cell line.
A the mam-domain-containing protein
Biological Determinants of and Reference Values for Plasma Interleukin-8, Monocyte Chemoattractant Protein-1, Endothelial Growth Factor (EGF), and Vascular EGF: Results from the STANISLAS Cohort
The results for IL-8, MCP-1, EGF, and VEGF may be useful for interpretation of patients’ laboratory results and for understanding the regulation of concentrations of these cytokines in physiologic conditions.