S. Fitzgerald

Publications7
h-index4
Citations138
Highly Influential Citations2
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The Synthetic Cannabinoid R(+)WIN 55,212-2 Inhibits the Interleukin-1 Signaling Pathway in Human Astrocytes in a Cannabinoid Receptor-independent Manner*
TLDR
Electrophoretic mobility shift and chromatin immunoprecipitation assays showed that R(+)WIN 55,212-2 does not regulate the IL-1-induced nuclear translocation of NFκB or the ability of the latter to bind to promoters regulating expression of ICAM-1 and IL-8.
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Molecular Analysis of the tagF Gene, Encoding CDP-Glycerol:Poly(glycerophosphate) Glycerophosphotransferase of Staphylococcus epidermidis ATCC 14990
TLDR
The cloned S. epidermidis tagF gene encodes a functional CDP-glycerol:poly(glyceroph phosphate) glycerophosphotransferase, which suggests that the tagf gene is essential and that the TagF and other enzymes involved in teichoic acid biosynthesis could be targets for new antistaphylococcal drugs.
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Tumour-necrosis-factor-receptor-associated factor 6, NF-kappaB-inducing kinase and IkappaB kinases mediate IgE isotype switching in response to CD40.
TLDR
The results suggest that CD40 employs TRAF-6, which presumably recruits NIK, which in turn employs IKK-1/IKK-2 to activate NF-kappaB and the Cepsilon promoter, the prologue to IgE switching, which defines a crucially important pathway in the generation of allergic states.
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CD40 employs p38 MAP kinase in IgE isotype switching.
TLDR
It is suggested that p38 MAPK is crucially important in mediating CD40 activation of NF kappa B which acts to induce C epsilon germline transcripts, ultimately facilitating IgE switching.
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Tumour-necrosis-factor-receptor-associated factor 6 , NF-κ B-inducing kinase and I κ B kinases mediate IgE isotype switching in response to CD 40
TLDR
The present study explores the uncharacterized signalling pathways employed by CD40 in activating NF-κB by the overexpression of genes encoding wildtype and dominant-negative forms of the signalling components tumour-necrosis-factor-receptor-associated factor 6 (TRAF-6), NF-β-inducing kinase, NIK, IκB kinase (IKK)-1 and IKK-2 in the BJAB B-cell line.
A the mam-domain-containing protein
Biological Determinants of and Reference Values for Plasma Interleukin-8, Monocyte Chemoattractant Protein-1, Endothelial Growth Factor (EGF), and Vascular EGF: Results from the STANISLAS Cohort
TLDR
The results for IL-8, MCP-1, EGF, and VEGF may be useful for interpretation of patients’ laboratory results and for understanding the regulation of concentrations of these cytokines in physiologic conditions.