• Publications
  • Influence
Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?
Establishment of the human placenta requires that fetal cytotrophoblast stem cells in anchoring chorionic villi become invasive. These cytotrophoblasts aggregate into cell columns and invade both theExpand
  • 882
  • 43
  • PDF
Implantation and the placenta: key pieces of the development puzzle.
The mammalian embryo cannot develop without the placenta. Its specialized cells (trophoblast, endoderm, and extraembryonic mesoderm) form early in development. They attach the embryo to the uterusExpand
  • 1,276
  • 36
Preterm labor: One syndrome, many causes
Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leadsExpand
  • 813
  • 33
  • PDF
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?
In human pregnancy, placental cytotrophoblasts that invade the uterus downregulate the expression of adhesion receptors that are characteristic of their epithelial origin, and upregulate theExpand
  • 844
  • 32
  • PDF
Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.
Development of the human embryo depends on the ability of first trimester cytotrophoblastic stem cells to differentiate and invade the uterus. In this process, transient expression of an invasiveExpand
  • 640
  • 28
  • PDF
A class I antigen, HLA-G, expressed in human trophoblasts.
The alpha chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associatedExpand
  • 1,297
  • 27
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.
FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependentExpand
  • 345
  • 26
  • PDF
Human Cytomegalovirus Infection of Placental Cytotrophoblasts In Vitro and In Utero: Implications for Transmission and Pathogenesis
ABSTRACT Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis ofExpand
  • 277
  • 26
  • PDF
92-kD type IV collagenase mediates invasion of human cytotrophoblasts
The specialized interaction between embryonic and maternal tissues is unique to mammalian development. This interaction begins with invasion of the uterus by the first differentiated embryonic cells,Expand
  • 714
  • 23
  • PDF
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.
Trophoblasts, the specialized cells of the placenta, play a major role in implantation and formation of the maternal-fetal interface. Through an unusual differentiation process examined in thisExpand
  • 563
  • 22
  • PDF