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Phytochemistry and pharmacognosy of the genus Acronychia.
The aim of this review is to examine in detail from a phytochemical and pharmacologically point of view what is reported in the current literature about the properties of phytopreparations or individual active principles obtained from plants belonging to the Acronychia genus.
Screening for novel plant sources of prenyloxyanthraquinones: Senna alexandrina Mill. and Aloe vera (L.) Burm. F.
- F. Epifano, S. Fiorito, M. Locatelli, V. A. Taddeo, S. Genovese
- Medicine, BiologyNatural product research
- 17 January 2015
The extraction and HPLC separation of madagascin and 3-geranyloxyemodine from dried leaves and fruits of Senna alexandrina Mill and Aloe vera are described.
Phytochemistry of the genus Skimmia (Rutaceae).
- F. Epifano, S. Fiorito, S. Genovese, S. Granica, S. Vitalini, C. Zidorn
- Biology, MedicinePhytochemistry
- 1 July 2015
The genus Skimmia is a rich source of interesting secondary metabolites, including 20 alkaloids derived from anthranilic acid, 45 coumarins, 21 limonoids, four cholestane derivatives, six pentacyclic…
Analysis of Biologically Active Oxyprenylated Ferulic Acid Derivatives in Citrus Fruits
- S. Genovese, S. Fiorito, M. Locatelli, G. Carlucci, F. Epifano
- Biology, MedicinePlant Foods for Human Nutrition
- 14 June 2014
A potential chemopreventive dietary feeding role for the Rutaceae spp.
Lapachol and its congeners as anticancer agents: a review
The aim of this review is to discuss in detail the phytochemical properties and pharmacological effects of the title compound that have been reported thus far, highlighting its potential therapeutic benefits for the future.
Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.
- S. Fiorito, F. Epifano, C. Bruyère, V. Mathieu, R. Kiss, S. Genovese
- Chemistry, MedicineBioorganic & medicinal chemistry letters
- 15 January 2014
A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro, revealing that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity.
Comparison of different extraction methods and HPLC quantification of prenylated and unprenylated phenylpropanoids in raw Italian propolis.
- V. A. Taddeo, F. Epifano, S. Fiorito, S. Genovese
- Medicine, ChemistryJournal of pharmaceutical and biomedical analysis
- 10 September 2016
"Classic" maceration in general performed better than ultrasound-assisted one in determining the presence of selected prenylated and unprenylated phenylpropanoids in Italian raw propolis after having been extracted with different methodologies.
A newly synthesized compound, 4′‐geranyloxyferulic acid–N(omega)‐nitro‐l‐arginine methyl ester suppresses inflammation‐associated colorectal carcinogenesis in male mice
- M. Shimizu, Takahiro Kochi, +6 authors H. Moriwaki
- Chemistry, MedicineInternational journal of cancer
- 15 August 2014
The findings indicate that GOFA–L‐NAME is able to inhibit colitis‐associated colon carcinogenesis by modulating inflammation, proliferation, apoptosis and the expression of proinflammatory cytokines in mice.
Enantioselective high-performance liquid chromatography analysis of oxygenated polyunsaturated fatty acids.
- F. Ianni, G. Saluti, R. Galarini, S. Fiorito, R. Sardella, B. Natalini
- Medicine, ChemistryFree radical biology & medicine
- 3 May 2019
In this review article, a selection of enantioseparation studies of different oxygenated PUFAs is reported, with both tris (benzoates) and tris(phenylcarbamates) of cellulose and amylose and both 4-methylbenzoate derivatives show the best enantioresolving ability.
Inhibition of nitric oxide production by natural oxyprenylated coumarins and alkaloids in RAW 264.7 cells
Abstract A series of naturally occurring 3,3-dimethylallyloxy- and geranyloxycoumarins and alkaloids were chemically synthesized and tested as anti-inflammatory agents for their inhibitory effects on…