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Conformational properties of biocompatible poly(2-ethyl-2-oxazoline)s in phosphate buffered saline
Inspired by the increasing popularity of poly(2-ethyl-2-oxazoline) (PEtOx) for biomedical applications, this study reports the complete and thorough solution analysis of the homologous series of…
Smart polymers in drug delivery systems on crossroads: Which way deserves following?
Macromolecular pHPMA-Based Nanoparticles with Cholesterol for Solid Tumor Targeting: Behavior in HSA Protein Environment.
- Xiaohan Zhang, Bart-Jan Niebuur, C. Papadakis
- Biology, Materials ScienceBiomacromolecules
- 30 January 2018
Mixed solutions of NPs, from polymer conjugates with or without the anticancer drug doxorubicin (Dox) bound to them, and HSA at concentrations up to the physiological value are characterized by synchrotron small-angle X-ray scattering and isothermal titration calorimetry.
Poly(2-oxazoline)s--are they more advantageous for biomedical applications than other polymers?
- O. Sedláček, Bryn D. Monnery, S. Filippov, R. Hoogenboom, M. Hrubý
- ChemistryMacromolecular rapid communications
- 15 October 2012
This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and commonly studied polymers in terms of their suitability for biomedical applications.
Multicompartment lipid cubic nanoparticles with high protein upload: millisecond dynamics of formation.
- B. Angelov, A. Angelova, S. Filippov, M. Drechsler, P. Štěpánek, S. Lesieur
- BiologyACS nano
- 17 April 2014
These time-resolved membrane processes, involving intercalation of discrete stiff proteins in continuous soft membranes, evidence stepwise curvature control mechanisms in nanostructure-based neuroprotection and biomimetic nanoarchitectonics.
Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein-Resistant Polymeric Coatings.
The novel synthesis of a polymeric interface grown from the surface of bright fluorescent nanodiamonds enables bioorthogonal attachment of various molecules by click chemistry and fully preserves the unique optical properties of the nitrogen-vacancy centers that are crucial for bioimaging and sensoric applications.
Thermoresponsive Polymer Micelles as Potential Nanosized Cancerostatics.
Convugates of thermoresponsive diblock copolymers with the covalently bound cancerostatic drug pirarubicin were synthesized as a reversible micelle-forming drug delivery system combining the benefits of the above-mentioned carriers and it was demonstrated that the studied conjugates have a great potential to become efficacious in vivo pharmaceuticals.
Effect of hydrophobic interactions on properties and stability of DNA-polyelectrolyte complexes.
- S. Filippov, Č. Koňák, P. Kopec̆ková, L. Starovoytová, M. Špírková, P. Štěpánek
- Chemistry, BiologyLangmuir : the ACS journal of surfaces and…
- 14 January 2010
The kinetics of turbidity ofpolyplexes solutions in physiological solution showed that the colloid stability of polyplexes increases with increasing content of cholesterol in polycations, and the properties of polycomplex particles depend, in addition to polycation structure, on the rate of polycation addition to DNA solutions.
Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study.
We report kinetic studies of therapeutically highly potent polymer-drug conjugates consisting of amphiphilic N-(2-hydroxypropyl) methacrylamide (HPMA)-based copolymers bearing the anticancer drug…