• Publications
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Bacterial dehalogenation
  • S. Fetzner
  • Medicine
  • Applied Microbiology and Biotechnology
  • 1998
The mechanisms of enzyme-catalyzed dehalogenation reactions are discussed, some pathways of the bacterial degradation of haloorganic compounds are described, and some trends in the biological treatment of organohalogen-polluted air, groundwater, soil, and sediments are indicated. Expand
Bacterial degradation of pyridine, indole, quinoline, and their derivatives under different redox conditions
  • S. Fetzner
  • Chemistry
  • Applied Microbiology and Biotechnology
  • 27 March 1998
Abstract Bacteria have evolved a diverse potential to transform and even mineralize numerous organic compounds of both natural and xenobiotic origin. This article describes the occurrence ofExpand
PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.
The data suggest that PqsE promotes the efficiency of alkylquinolone signal molecule biosynthesis in P. aeruginosa and balances the levels of secondary metabolites deriving from the alkylbenzoylacetyl-coenzyme A biosynthesis pathway. Expand
Bacterial dehalogenases: biochemistry, genetics, and biotechnological applications.
This review is a survey of bacterial dehalogenases that catalyze the cleavage of halogen substituents from haloaromatics, haloalkanes, haloalcohols, and haloalkanoic acids. Concerning the enzymaticExpand
Quorum quenching enzymes.
  • S. Fetzner
  • Biology, Medicine
  • Journal of biotechnology
  • 10 May 2015
Several approaches have been assessed which aim at alleviating virulence, or biofilm formation, by reducing the signal concentration in the bacterial environment, and these involve the application or stimulation of signal-degrading bacteria as biocontrol agents in the protection of crop plants against soft-rot disease. Expand
Cofactor-independent oxidases and oxygenases
Whereas the majority of O2-metabolizing enzymes depend on transition metal ions or organic cofactors for catalysis, a significant number of oxygenases and oxidases neither contain nor require anyExpand
Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt.
On the basis of spectroscopic data, and considering the organic chemistry of flavonols, the nonredox role of the metal center in catalysis is discussed. Expand
PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal
2-aminoacetophenone is identified as a pathway-inherent competitive inhibitor of PqsBC, whose fluorescence properties could be used for in vitro binding studies and it is demonstrated that the catalytic histidine is not involved in acyl-enzyme formation, but contributes to an acylation-dependent increase in affinity for the second substrate 2-ABA. Expand
Gene Cluster of Arthrobacter ilicis Rü61a Involved in the Degradation of Quinaldine to Anthranilate
Qox is the first MCD-containing enzyme to be synthesized in a catalytically fully competent form by a heterologous host, and the catalytic properties and the UV-visible and EPR spectra of Qox purified from P. putida KT2440 pKP1 were essentially like those of wild-type Qox. Expand
Purification and some properties of 2-halobenzoate 1,2-dioxygenase, a two-component enzyme system from Pseudomonas cepacia 2CBS
The two components of the inducible 2-halobenzoate 1,2-dioxygenase from Pseudomonas cepacia 2CBS were purified to homogeneity and exhibited a very broad substrate specificity, but benzoate analogs with electron-withdrawing substituents at the ortho position were transformed preferentially. Expand