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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, promoting the immune response to pathogens by activating the transcription factor NFAT. WeExpand
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Orai1 is an essential pore subunit of the CRAC channel
Stimulation of immune cells causes depletion of Ca2+ from endoplasmic reticulum (ER) stores, thereby triggering sustained Ca2+ entry through store-operated Ca2+ release-activated Ca2+ (CRAC)Expand
  • 1,148
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Calcium signalling in lymphocyte activation and disease
  • S. Feske
  • Medicine, Biology
  • Nature Reviews Immunology
  • 1 September 2007
Calcium signals in cells of the immune system participate in the regulation of cell differentiation, gene transcription and effector functions. An increase in intracellular levels of calcium ionsExpand
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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Sustained calcium signaling induces a state of anergy or antigen unresponsiveness in T cells, mediated through calcineurin and the transcription factor NFAT. We show here that Ca2+-induced anergy isExpand
  • 529
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Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
Store-operated Ca2+ entry through calcium release–activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblastsExpand
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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Activated T cells engage aerobic glycolysis and anabolic metabolism for growth, proliferation, and effector functions. We propose that a glucose-poor tumor microenvironment limits aerobic glycolysisExpand
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STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity.
A mutation in ORAI1, the gene encoding the pore-forming subunit of the Ca(2+)-release-activated Ca(2+) (CRAC) channel, abrogates the store-operated entry of Ca(2+) into cells and impairs lymphocyteExpand
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Biochemical and Functional Characterization of Orai Proteins*
Stimulation of immune cells triggers Ca2+ entry through store-operated Ca2+ release-activated Ca2+ channels, promoting nuclear translocation of the transcription factor NFAT. Through genome-wide RNAExpand
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Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice
Mushroom dendritic spine structures are essential for memory storage, and the loss of mushroom spines may explain memory defects in Alzheimer's disease (AD). Here we show a significant reduction inExpand
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A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Precise regulation of the NFAT (nuclear factor of activated T cells) family of transcription factors (NFAT1–4) is essential for vertebrate development and function. In resting cells, NFAT proteinsExpand
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