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Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue
TLDR
An analgesic tripeptide analogue of IL-1β is developed which antagonizes hyperalgesia evoked by IL- 1β and by the inflammatory agent carrageenan.
Central and peripheral antialgesic action of aspirin-like drugs.
Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia
TLDR
Data show that bradykinin can initiate the cascade of cytokine release that mediates hyperalgesic responses to carrageenin and endotoxin, and suggests that the release of hyperAlgesic cytokines can be initiated independently of bradyKinin BK2 receptors.
Morphine peripheral analgesia depends on activation of the PI3Kγ/AKT/nNOS/NO/KATP signaling pathway
TLDR
It is shown that the peripheral antinociceptive effect of morphine is lost in neuronal nitric-oxide synthase null mice and that morphine induces the production of nitric oxide in primary nociception neurons.
A peripheral sympathetic component in inflammatory hyperalgesia.
Peripheral hyperalgesic cytokines.
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