• Publications
  • Influence
Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia
Increasing evidence suggests that antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the basal ganglia are involved in the motor depressant effects ofExpand
  • 749
  • 54
Involvement of Adenosine A1 and A2A Receptors in the Motor Effects of Caffeine after its Acute and Chronic Administration
The involvement of adenosine A1 and A2A receptors in the motor effects of caffeine is still a matter of debate. In the present study, counteraction of the motor-depressant effects of the selective A1Expand
  • 175
  • 11
Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat
Electrical stimulation techniques were employed in the chloral hydrate anaesthetized male rat to evaluate if the pontine noradrenergic nucleus locus coeruleus can influence the activity of midbrainExpand
  • 228
  • 11
Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
The striatum contains a high density of histamine H(3) receptors, but their role in striatal function is poorly understood. Previous studies have demonstrated antagonistic interactions betweenExpand
  • 147
  • 11
Adenosine A2A Agonists: A Potential New Type of Atypical Antipsychotic
The systemic intraperitoneal (i.p.) administration of the adenosine A2A agonist CGS 21680 was found to dose-dependently antagonize spontaneous and amphetamine-induced (1 mg/kg i.p.) motor activityExpand
  • 144
  • 9
Postsynaptic antagonistic interaction between adenosine A1, and dopamine D1 receptors
BEHAVIOURAL, AND biochemical evidence for the existence of a powerful specific postsynaptic interaction between adenosine A1, and dopamine D1 receptors in the mammalian brain was found. BehaviouralExpand
  • 131
  • 7
Evidence for Adenosine/Dopamine Receptor Interactions: Indications for Heteromerization
Evidence has been obtained for adenosine/dopamine interactions in the central nervous system. There exists an anatomical basis for the existence of functional interactions between adenosine A1R andExpand
  • 150
  • 7
The Selective mGlu5 Receptor Agonist CHPG Inhibits Quinpirole-Induced Turning in 6-Hydroxydopamine-Lesioned Rats and Modulates the Binding Characteristics of Dopamine D2 Receptors in the Rat Striatum
In 6-hydroxydopamine-lesioned rats, the selective mGlu5 receptor agonist (RS)-2-Cholro-5-Hydroxyphenylglycine (CHPG, 1-6 μg/10 μl intracerebroventricularly) significantly inhibited contralateralExpand
  • 126
  • 7
Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia
Recent studies have shown the existence of a specific antagonistic interaction between adenosine A2a receptors and dopamine D2 receptors in the brain. This A2a-D2 interaction seems to be essentialExpand
  • 167
  • 6
Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A2A and dopamine D2 receptors
Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA)ergic efferentExpand
  • 117
  • 5