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A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. Expand
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.
- X. Guan, H. Yu, +6 authors A. Howard
- Biology, Medicine
- Brain research. Molecular brain research
- 1 August 1997
The demonstration of hypothalamic and pituitary localization of the GHS-R is consistent with its role in regulating growth hormone release and the expression of the receptor in other central and peripheral regions may implicate its involvement in additional as yet undefined physiological functions. Expand
Identification of receptors for neuromedin U and its role in feeding
It is shown that the previously described orphan G-protein-coupled receptor FM-3 and a newly discovered one (FM-4) are cognate receptors for NMU, which provides a molecular basis for the biochemical activities of NMU and may indicate that NMU is involved in the central control of feeding. Expand
Peptidomimetic regulation of growth hormone secretion.
- R. Smith, L. V. D. van der Ploeg, +7 authors A. Patchett
- Biology, Medicine
- Endocrine reviews
- 1 October 1997
This work has shown that the mechanism of action of GHRH, GHRP-6, and somatostatin in the Central Nervous System and the role of GHS-R in regulating Pulsatile GH Release is determined through in vitro and clinical studies. Expand
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.
The results establish an in vivo orexigenic function for NPY and AgRP, mediating the effect of ghrelin, as well as the involvement of the melanocortin pathway inghrelin signaling. Expand
Phylogenetic relationships among eight Eimeria species infecting domestic fowl inferred using complete small subunit ribosomal DNA sequences.
- J. Barta, D. S. Martin, +9 authors H. Profous-Juchelka
- Biology, Medicine
- The Journal of parasitology
- 1 April 1997
Clades of avian Eimeria species and the apparent absence of coccidia that infect the ceca of jungle fowl all suggest that E. necatrix and E. tenella may have arisen from a host switch, perhaps from the North American turkey, Meleagris gallopavo. Expand
Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.
- M. Bednarek, S. Feighner, +7 authors J. Heck
- Chemistry, Medicine
- Journal of medicinal chemistry
- 26 October 2000
The entire sequence of ghrelin is not necessary for activity: the Gly-Ser-Ser(n-octanoyl)-Phe segment appears to constitute the "active core" required for agonist potency at hGHSR1a. Expand
Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.
The recent cloning of the GHS-R from human and swine pituitary gland identifies yet a third G protein-coupled receptor (GPC-R) involved in the control of GH release and further supports the existence of an undiscovered hormone that may activate this receptor. Expand
Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.
The recent cloning of a growth hormone secretagogue receptor (GHS-R) from human pituitary gland and brain identified a third G protein-coupled receptor (GPC-R) involved in the control of growth… Expand
Development of a differential medium for bile salt hydrolase-active Lactobacillus spp
The availability of a differential medium for determination of bile salt hydrolase activity will provide a rapid method for determining shifts in a specific functional activity of intestinal Lactobacillus species and provide aRapid screening capability for identifying bile Salt hydrolases-deficient mutants. Expand