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The importance of the viable but non-culturable state in human bacterial pathogens
TLDR
The characteristics of VBNC cells, including the similarities and differences to viable, culturable cells and dead cells, and different detection methods are discussed, and their potential influence on human health is reviewed. Expand
Transcriptome of Salmonella enterica serovar Typhi within macrophages revealed through the selective capture of transcribed sequences.
TLDR
The combined use of selective capture of transcribed sequences and microarrays is an effective way to determine the bacterial transcriptome in vivo and could be used to investigate transcriptional profiles of other bacterial pathogens without the need to recover many nanograms of bacterial mRNA from host and without increasing the multiplicity of infection beyond what is seen in nature. Expand
Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages
TLDR
This study provides a comprehensive view of how L. pneumophila responds to the human macrophage intracellular environment and predicts previously unrecognized Icm/Dot effector genes based on their expression pattern and confirmed translocation for three candidates. Expand
SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.
TLDR
The characterization of the L. pneumophila small RNA csrB homologs, rsmY and rsmZ, introduces a link between sigma(S) and the posttranscriptional regulator CsrA and shows that sigma (S) is a key regulator of multiple pathways required for L.neumophila intracellular multiplication. Expand
Escherichia coli O157:H7 Survives within Human Macrophages: Global Gene Expression Profile and Involvement of the Shiga Toxins
TLDR
The uptake and survival of strain EDL933 during infection of human macrophages was evaluated and the initial uptake of Shiga toxins mutants was higher than that of the wild type; however, the survival rates were significantly lower at 24 h postinfection. Expand
Legionella pneumophila 6S RNA optimizes intracellular multiplication
TLDR
One of the identified sRNAs is highly expressed in postexponential phase, and computational prediction of its secondary structure reveals a striking similarity to the structure of 6S RNA, a widely distributed prokaryotic sRNA, known to regulate the activity of σ70-containing RNA polymerase. Expand
A novel PhoP-regulated locus encoding the cytolysin ClyA and the secreted invasin TaiA of Salmonella enterica serovar Typhi is involved in virulence.
TLDR
It is demonstrated that TaiA is secreted independently of both the Salmonella pathogenicity island (SPI)-1 and the SPI-2 type three secretion systems and regulated by the virulence-associated regulator PhoP. Expand
ArgR-regulated genes are derepressed in the Legionella-containing vacuole.
TLDR
Evidence is presented that the concentration of L-arginine in the LCV is sensed by ArgR to produce an intracellular transcriptional response and suggests that L- arginine availability functions as a regulatory signal during Legionnaires' disease. Expand
Contribution of the stg Fimbrial Operon of Salmonella enterica Serovar Typhi during Interaction with Human Cells
TLDR
Results show that the stg operon may encode a functional fimbria, and this serovar Typhi-specific fimbrial operon contributes to interactions with host cells, and further characterization is important for understanding the role of the stG fimbrian cluster in typhoid fever pathogenesis. Expand
The CpxRA two‐component system contributes to Legionella pneumophila virulence
TLDR
It is found that cpxR is essential for intracellular replication within Acanthamoeba castellanii, but not in U937‐derived macrophages, and the CpxRA system is a key contributor to L. pneumophila virulence in protozoa via virulence factor regulation. Expand
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