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Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.
TLDR
The results demonstrate that, in the UCMS paradigm, AMPAR activation exhibits antidepressant-like activity that relates preferentially to specific depressive-like responses and that those specific responses can be defined by their regulation by AMPAR modulation under conditions of stress.
Maternal deprivation increases behavioural reactivity to stressful situations in adulthood: suppression by the CCK2 antagonist L365,260
TLDR
The results suggest that maternal deprivation led to an increase in anxiety and stress reactivity in adulthood, and it is proposed that these long-lasting changes are partly dependent on CCKergic transmission involving the activation of CCK2 receptors.
Antidepressive effects of targeting ELK-1 signal transduction
TLDR
This work stresses the importance of target selectivity for a successful approach for signal-transduction-based antidepressants, singles out ELK-1 as a depression-relevant transducer downstream of ERK and brings proof-of-concept evidence for the druggability of ELK1.
Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model
TLDR
It is shown that in mice, early life adversity affected the expression of the set of genes in peripheral blood, and that levels of expression correlated with symptoms of negative affect in adolescence, which provides a novel validated gene-set of immune-related genes for further research in the early stages of mood disorders.