Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.
- S. Farley, Kalliopi Apazoglou, J. Witkin, B. Giros, E. Tzavara
- Psychology, BiologyThe international journal of…
- 1 October 2010
The results demonstrate that, in the UCMS paradigm, AMPAR activation exhibits antidepressant-like activity that relates preferentially to specific depressive-like responses and that those specific responses can be defined by their regulation by AMPAR modulation under conditions of stress.
Selective cortical VGLUT1 increase as a marker for antidepressant activity
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin–Lowry syndrome
Antipsychotics increase vesicular glutamate transporter 2 (VGLUT2) expression in thalamolimbic pathways
Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: Effects of…
Maternal deprivation increases behavioural reactivity to stressful situations in adulthood: suppression by the CCK2 antagonist L365,260
The results suggest that maternal deprivation led to an increase in anxiety and stress reactivity in adulthood, and it is proposed that these long-lasting changes are partly dependent on CCKergic transmission involving the activation of CCK2 receptors.
Antidepressive effects of targeting ELK-1 signal transduction
This work stresses the importance of target selectivity for a successful approach for signal-transduction-based antidepressants, singles out ELK-1 as a depression-relevant transducer downstream of ERK and brings proof-of-concept evidence for the druggability of ELK1.
P.2.d.019 Phenotypic variability of chronic stress vulnerability studied in two strain of mice: focus on the glutamatergic system
- S. Farley
- BiologyEuropean Neuropsychopharmacology
- 1 October 2007
109. From Early Life Adversity to Adolescence Depression: White Matter Remodelling in a Translational Animal Model
Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model
- Lukas Penninck, E. C. Ibrahim, J. Martinot
- Psychology, BiologyFrontiers in Systems Neuroscience
- 30 September 2021
It is shown that in mice, early life adversity affected the expression of the set of genes in peripheral blood, and that levels of expression correlated with symptoms of negative affect in adolescence, which provides a novel validated gene-set of immune-related genes for further research in the early stages of mood disorders.