• Publications
  • Influence
Viral infections: A double whammy for hep C
  • S. Farley
  • Medicine
  • Nature Reviews Drug Discovery
  • 1 June 2003
Persistent hepatitis C virus (HCV) infections — the main cause of liver disease worldwide — are a function of the ability of HCV to block its host's innate immune response. Expression of interferonExpand
Synaptic plasticity: Ups and downs of cerebellar plasticity
  • S. Farley
  • Biology
  • Nature Reviews Neuroscience
  • 1 February 2004
TLDR
Light is shed on interactions between long-term potentiation (LTP) and LTD in the mammalian cerebellum and on the model in which nitric oxide participates in the induction of synaptic plasticity, which takes the form of LTD or LTP depending on coincident elevation of postsynaptic calcium. Expand
Sexual dysfunction: Postorgasmic illness syndrome
  • S. Farley
  • Medicine
  • Nature Reviews Urology
  • 1 March 2011
New evidence supports the hypothesis that postorgasmic illness syndrome (POIS) in men involves a hyper-reactive immune response of the mucosal epithelium that lines the urinary tract to seminal fluid.
BPH: Lift and separate to relieve LUTS
  • S. Farley
  • Medicine
  • Nature Reviews Urology
  • 14 June 2011
TLDR
The authors assert that the prostatic lift procedure offers superior symptomatic relief to medical therapy and a better patient experience than other minimally-invasive surgeries. Expand
Prostate cancer: XMRV—contaminant, not cause?
  • S. Farley
  • Medicine
  • Nature Reviews Urology
  • 12 July 2011
TLDR
New evidence indicates that XMRV is an artifact generated during production of prostate cancer cell lines, and is not associated with prostatic malignancy. Expand
Gpcrs: A solid view of GPCRs
  • S. Farley
  • Medicine
  • Nature Reviews Drug Discovery
  • 1 November 2003
TLDR
Hsp90 in tumour cells exists in a functionally distinct molecular form that has a 100-fold higher affinity for the Hsp90 inhibitor 17-allylaminogeldanamycin (17-AAG; now in Phase I clinical trials) than Hsp 90 from normal cells. Expand
Two wrongs make a right
  • S. Farley
  • Biology
  • Nature Reviews Neuroscience
  • 1 June 2003
TLDR
There is compelling evidence that the cerebellum itself produces long-range, diffusible guidance cues, and it is thought that the growing axons are attracted to the floor plate by guidance molecules such as netrin-1, and their final topographic organization seems to be determined by local signals within the Cerebellum that act over a short range. Expand
Metabolic syndrome: Two for the price of one
  • S. Farley
  • Medicine
  • Nature Reviews Drug Discovery
  • 1 June 2004
TLDR
It is clear that telmisartan acts on both angiotensin receptors and PPAR-γ, and could therefore be a first line of defence against the metabolic syndrome that commonly presages cardiovascular disease and type 2 diabetes. Expand
Prostate cancer: Risk stratification of PSA-based screening
  • S. Farley
  • Medicine
  • Nature Reviews Urology
  • 8 December 2010
TLDR
It is suggested that risk-based selection of men for screening will dramatically refine this approach to cancer detection, and that risk stratifying prostate cancer screening could retain most of the benefits—in terms of reduced mortality—and avoid much of the harm. Expand
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