Skip to search formSkip to main contentSkip to account menu
Viral infections: A double whammy for hep C
  • S. Farley
  • Biology, Medicine
    Nature Reviews Drug Discovery
  • 1 June 2003
Persistent hepatitis C virus (HCV) infections — the main cause of liver disease worldwide — are a function of the ability of HCV to block its host's innate immune response. Expression of interferon…
View on Springer
Synaptic plasticity: Ups and downs of cerebellar plasticity
  • S. Farley
  • Biology
    Nature Reviews Neuroscience
  • 1 February 2004
TLDR
Light is shed on interactions between long-term potentiation (LTP) and LTD in the mammalian cerebellum and on the model in which nitric oxide participates in the induction of synaptic plasticity, which takes the form of LTD or LTP depending on coincident elevation of postsynaptic calcium.
View on Springer
Sexual dysfunction: Postorgasmic illness syndrome
  • S. Farley
  • Medicine
    Nature Reviews Urology
  • 1 March 2011
New evidence supports the hypothesis that postorgasmic illness syndrome (POIS) in men involves a hyper-reactive immune response of the mucosal epithelium that lines the urinary tract to seminal fluid.
View on Nature
BPH: Lift and separate to relieve LUTS
  • S. Farley
  • Medicine
    Nature Reviews Urology
  • 14 June 2011
TLDR
The authors assert that the prostatic lift procedure offers superior symptomatic relief to medical therapy and a better patient experience than other minimally-invasive surgeries.
View on Nature
Prostate cancer: XMRV—contaminant, not cause?
  • S. Farley
  • Biology, Medicine
    Nature Reviews Urology
  • 12 July 2011
TLDR
New evidence indicates that XMRV is an artifact generated during production of prostate cancer cell lines, and is not associated with prostatic malignancy.
View on Nature
Infection: The shortcomings of standard tests and treatments for UTI.
View on PubMed
Gpcrs: A solid view of GPCRs
  • S. Farley
  • Biology
    Nature Reviews Drug Discovery
  • 1 November 2003
TLDR
Hsp90 in tumour cells exists in a functionally distinct molecular form that has a 100-fold higher affinity for the Hsp90 inhibitor 17-allylaminogeldanamycin (17-AAG; now in Phase I clinical trials) than Hsp 90 from normal cells.
View on Nature
Two wrongs make a right
  • S. Farley
  • Biology
    Nature Reviews Neuroscience
  • 1 June 2003
TLDR
There is compelling evidence that the cerebellum itself produces long-range, diffusible guidance cues, and it is thought that the growing axons are attracted to the floor plate by guidance molecules such as netrin-1, and their final topographic organization seems to be determined by local signals within the Cerebellum that act over a short range.
View on Nature
Acute kidney injury/acute renal failure: standardizing nomenclature, definitions and staging
  • S. Farley
  • Medicine, Biology
    Nature Clinical Practice Nephrology
  • 1 August 2007
Acute kidney injury/acute renal failure: standardizing nomenclature, definitions and staging
View on Nature
Metabolic syndrome: Two for the price of one
  • S. Farley
  • Biology
    Nature Reviews Drug Discovery
  • 1 June 2004
TLDR
It is clear that telmisartan acts on both angiotensin receptors and PPAR-γ, and could therefore be a first line of defence against the metabolic syndrome that commonly presages cardiovascular disease and type 2 diabetes.
View on Springer
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License