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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
TLDR
The use of RAPA, instead of cyclosporine, may reduce the chance of recurrent or de novo cancer in high-risk transplant patients and show antiangiogenic activities linked to a decrease in production of vascular endothelial growth factor and to a markedly inhibited response ofascular endothelial cells to stimulation by VEGF.
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes
Background  The adipokine chemerin modulates the function of innate immune cells and may link obesity and inflammation, and therefore, a possible relation of chemerin to inflammatory proteins in
Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes.
CONTEXT Adipocytes synthesize galectin-3 whose deficiency protects from inflammation associated with metabolic diseases. We aimed to study circulating galectin-3 in obesity and type 2 diabetes (T2D).
Analysis of intestinal haem‐oxygenase‐1 (HO‐1) in clinical and experimental colitis
TLDR
The data suggest a protective role of HO‐1 if it is induced before the onset of inflammation, however, as shown by the lack of effects in established acute or in chronic colitis, the induction ofHO‐1 may not be a promising approach for the treatment of IBD.
A comprehensive genotype-phenotype interaction of different Toll-like receptor variations in a renal transplant cohort.
TLDR
The present study in renal transplant recipients suggests that the TLR system may be involved in both acute rejection and MACE, and may be a promising target in future therapeutic strategies.
Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils.
TLDR
Adhesion blockade or neutrophil depletion aggravates rat TNBS/DNBS-induced colitis together with extraintestinal manifestations of the eyes, and neutrophils appear to have an important role in mucosal repair processes.
Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings
TLDR
Two-step hepatic resection performing surgical exploration, PVL, and ISS results in a marked and rapid hypertrophy of functional liver tissue and enables curative resection of marginally resectable liver tumors or metastases in patients that might otherwise be regarded as palliative.
Macrophages Driven to a Novel State of Activation Have Anti-Inflammatory Properties in Mice1
TLDR
It is concluded that IFNγ-MdC represent macrophages in a novel state of activation, possessing multiple T cell-suppressive effects with therapeutic potential for the treatment of autoimmune inflammation.
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