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p53 Activation by Knockdown Technologies
TLDR
It is shown here that MO off-targeting results in induction of a p53-dependent cell death pathway, and p53 inhibition could potentially be applicable to other systems to suppress off- target effects caused by other knockdown technologies.
Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters
TLDR
Zebrafish mutants, such as fat free, that show normal digestive organ morphology but severely reduced phospholipid and cholesterol processing are identified, indicating genes that mediate vertebrate digestive physiology.
sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development
TLDR
Zebrafish data reveal key roles for SOX9 in the morphogenesis of the pancreaticobiliary ductal system, and cast human Sox9 as a candidate gene for pancreaticOBiliary duct malformation-related pathologies.
Tim50, a Component of the Mitochondrial Translocator, Regulates Mitochondrial Integrity and Cell Death*
TLDR
Observations indicate that loss of Tim50 in vertebrates causes mitochondrial membrane permeabilization and dysfunction followed by cytoplasmic release of cytochrome c along with other mitochondrial inducers of cell death.
Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.
Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish
TLDR
The feasibility of identifying novel inhibitors of intestinal lipid absorption using the zebrafish system is demonstrated and these findings support the utility of zebra fish screening assays to identify novel compounds that target complex physiological processes.
D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish
TLDR
The results obtained further corroborate the concept that HS encodes information that affect morphogenesis during early vertebrate development and that Glce acts during gastrulation by affecting Bmp-mediated cell specification.
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