S. Falkow

Publications515
h-index141
Citations68,441
Highly Influential Citations2,466
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FACS-optimized mutants of the green fluorescent protein (GFP).
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Macrophage‐dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival
TLDR
It is concluded that SPI‐2 genes are specifically expressed upon entry into mammalian cells and are required for intracellular growth in host cells in vivo and in vitro.
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Fluorescence-based isolation of bacterial genes expressed within host cells.
TLDR
A selection strategy was devised to identify bacterial genes preferentially expressed when a bacterium associates with its host cell, which should be generally applicable to the identification of genes from pathogenic organisms that are induced upon association with host cells or tissues.
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Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches
TLDR
Invasion of M cells was associated with the ability of the bacteria to invade tissue culture cells, and replicating Salmonella began to enter both the apical and basolateral surfaces of enterocytes adjacent to infected M cells.
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Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans.
TLDR
YEGFP3 can be used as a versatile reporter of gene expression in C. albicans and Saccharomyces cerevisiae and the optimized GFP described here should have broad applications in these and other fungal species.
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Common themes in microbial pathogenicity revisited.
TLDR
Comprehension of common themes in microbial pathogenicity is critical to the understanding and study of bacterial virulence mechanisms and to the development of new "anti-virulence" agents, which are so desperately needed to replace antibiotics.
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The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1.
TLDR
The data demonstrate that SipB functions as an analog of the Shigella invasin IpaB, and functional inhibition of caspase-1 activity by acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone blocks macrophage cytotoxicity, and macrophages lacking casp enzyme are not susceptible to Salmonella-induced apoptosis.
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Persistent bacterial infections: the interface of the pathogen and the host immune system
TLDR
The nature of the host immune response to this type of infection and the balance between clearance of the pathogen and avoidance of damage to host tissues are discussed.
View on Nature
Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA
TLDR
It is shown that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-Junction components at sites of bacterial attachment, and altering the composition and function of the apical- junctional complex.
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Interaction of Mycobacterium avium with environmental amoebae enhances virulence
TLDR
Data suggest a role for protozoa present in water environments as hosts for pathogenic mycobacteria, particularly M. avium in amoebae, which enhances both entry and intracellular replication compared to growth of bacteria in broth.
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