S. Fahn

Publications853
h-index118
Citations67,867
Highly Influential Citations2,626
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Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results
TLDR
The combined clinimetric results of this study support the validity of the MDS‐UPDRS for rating PD.
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Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Thirteen families have been described with an autosomal dominantly inherited dementia named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), historically termed Pick's…
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Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Process, format, and clinimetric testing plan
TLDR
The MDS‐UPDRS retains the UPDRS structure of four parts with a total summed score, but the parts have been modified to provide a section that integrates nonmotor elements of PD: I, Nonmotor Experiences of Daily Living; II, Motor Exper experiences of daily Living; III, Motor Examination; and IV, Motor Complications.
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Unified Parkinson's Disease Rating Scale
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Levodopa and the progression of Parkinson's disease.
TLDR
The clinical data suggest that levodopa either slows the progression of Parkinson's disease or has a prolonged effect on the symptoms of the disease, and the neuroimaging data suggest either thatlevodopa accelerates the loss of nigrostriatal dopamine nerve terminals or that its pharmacologic effects modify the dopamine transporter.
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Phenomenology and classification of dystonia: A consensus update
TLDR
An international panel consisting of investigators with years of experience in this field that reviewed the definition and classification of dystonia provides a new general definition and proposes a new classification and encourages clinicians and researchers to use these innovative definitions and test them in the clinical setting on a variety of patients with Dystonia.
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Validity and reliability of a rating scale for the primary torsion dystonias
TLDR
The Movement Scale was a valid and reliable indicator of the severity of primary torsion dystonia and was found to be compatible with scores on the Disability Scale.
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Description of Parkinson's Disease as a Clinical Syndrome
  • S. Fahn
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 1 June 2003
TLDR
Clinical fluctuations and dyskinesias are frequent complications of levodopa therapy; these, as well as some motor features of PD, improve by resetting the abnormal brain physiology towards normal by surgical therapy.
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The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein
TLDR
The DYT1 gene on human chromosome 9q34 is identified as being responsible for early-onset torsion dystonia, a movement disorder, characterized by twisting muscle contractures, that begins in childhood.
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