Evolution of NADH dehydrogenase subunit 2 in east African cichlid fish.
- T. Kocher, J. Conroy, K. McKaye, J. R. Stauffer, S. F. Lockwood
- BiologyMolecular Phylogenetics and Evolution
- 1 December 1995
Phylogenetic analysis of the sequences shows that the mtDNA variation in Lake Malawi cichlids is nested monophyletically within the range of variation shown by Tanganyikan cichLids, and Divergences among tribes are consistent with an intralacustrine radiation within the past 10 million years.
Acute and chronic administration of disodium disuccinate astaxanthin (CardaxTM) produces marked cardioprotection in dog hearts
- G. Gross, S. F. Lockwood
- Biology, MedicineMolecular and Cellular Biochemistry
- 1 April 2005
CardaxTM may be a novel and powerful new means to prevent myocardial injury and/or necrosis associated with elective and/ or urgent cardiac surgical interventions such as coronary angioplasty and stenting, as well as coronary artery bypass surgery (CABG).
Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis.
- Hyesun P McNulty, J. Byun, S. F. Lockwood, R. Jacob, R. Mason
- Chemistry, PhysicsBiochimica et Biophysica Acta
- 2007
Novel astaxanthin prodrug (CDX-085) attenuates thrombosis in a mouse model.
- S. Khan, T. Malinski, P. Bodary
- Biology, MedicineThrombosis Research
- 1 October 2010
The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters.
- Geoff Nadolski, A. Cardounel, J. Zweier, S. F. Lockwood
- ChemistryBioorganic & Medicinal Chemistry Letters
- 15 February 2006
Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives.
- Laura M. Hix, S. F. Lockwood, J. Bertram
- Biology, ChemistryCancer Letters
- 28 July 2004
Rofecoxib Increases Susceptibility of Human LDL and Membrane Lipids to Oxidative Damage: A Mechanism of Cardiotoxicity
- R. Preston Mason, M. Walter, R. Jacob
- Biology, MedicineJournal of Cardiovascular Pharmacology
- 1 June 2006
It is confirmed that the prooxidant activity of rofecoxib can be blocked by the potent antioxidant astaxanthin in homochiral form (all-trans 3S, 3′S), which provides a mechanistic rationale for differences in cardiovascular risk among COX-selective inhibitors because of their intrinsic physicochemical properties.
Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative.
- Laura M. Hix, D. Frey, M. Mclaws, M. Østerlie, S. F. Lockwood, J. Bertram
- Biology, ChemistryCarcinogenesis
- 1 September 2005
A novel tetrasodium diphosphate astaxanthin (pAST) derivative is synthesized with dual properties of water dispersibility (enabling parenteral administration in vivo) and increased potency that should prove extremely useful in the future development of cancer chemopreventive agents.
Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron…
- A. Cardounel, C. Dumitrescu, J. Zweier, S. F. Lockwood
- ChemistryBiochemical and Biophysical Research…
- 1 August 2003
Seven day oral supplementation with Cardax TM (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats
- G. Gross, S. Hazen, S. F. Lockwood
- BiologyMolecular and Cellular Biochemistry
- 1 February 2006
The potential utility of this compound for cardioprotection to the elective human cardiovascular patient population is extended, for which 7-day oral pre-treatment (as with statins) provides significant reductions in induced periprocedural infarct size.
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