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- Publications
- Influence
Pharmacokinetics of Metformin during Pregnancy
- S. Eyal, T. Easterling, +9 authors M. Hebert
- Medicine
- Drug Metabolism and Disposition
- 1 May 2010
Our objective was to evaluate the pharmacokinetics of metformin during pregnancy. Serial blood and urine samples were collected over one steady-state dosing interval in women treated with metformin… Expand
Drug interactions at the blood-brain barrier: fact or fantasy?
- S. Eyal, P. Hsiao, J. Unadkat
- Biology, Medicine
- Pharmacology & therapeutics
- 1 July 2009
There is considerable interest in the therapeutic and adverse outcomes of drug interactions at the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). These include altered… Expand
Novel levodopa gastroretentive dosage form: in-vivo evaluation in dogs.
- E. Klausner, S. Eyal, E. Lavy, M. Friedman, A. Hoffman
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 14 February 2003
Due to its narrow absorption window, levodopa has to be administered continuously to the upper parts of the intestine in order to maintain sustained therapeutic levels. This may be achieved by a… Expand
The Activity of Antiepileptic Drugs as Histone Deacetylase Inhibitors
- S. Eyal, B. Yagen, E. Sobol, Y. Altschuler, M. Shmuel, M. Bialer
- Chemistry, Medicine
- Epilepsia
- 1 July 2004
Summary: Purpose: Valproic acid (VPA), one of the widely used antiepileptic drugs (AEDs), was recently found to inhibit histone deacetylases (HDACs). HDAC inhibitors of a wide range of structures,… Expand
CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance
- Adam J. Claessens, L. Risler, S. Eyal, D. Shen, T. Easterling, M. Hebert
- Chemistry, Medicine
- Drug Metabolism and Disposition
- 22 June 2010
Clonidine is a centrally acting, α-2 adrenergic agonist used for the treatment of hypertension during pregnancy. The metabolic pathways of clonidine are poorly understood, and the quantitative… Expand
Prediction of binaural click lateralization by brainstem auditory evoked potentials
- M. Furst, S. Eyal, A. Korczyn
- Psychology, Medicine
- Hearing Research
- 1 November 1990
A previous study by Furst et al. (1985) has shown that in healthy subjects brainstem responses evoked by binaural auditory stimuli with interaural time difference (ITD) and interaural level… Expand
The antiepileptic and anticancer agent, valproic acid, induces P‐glycoprotein in human tumour cell lines and in rat liver
- S. Eyal, J. Lamb, +5 authors M. Bialer
- Biology, Medicine
- British journal of pharmacology
- 25 September 2006
The antiepileptic drug valproic acid, a histone deacetylase (HDAC) inhibitor, is currently being tested as an anticancer agent. However, HDAC inhibitors may interact with anticancer drugs through… Expand
Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.
- S. Eyal, B. Yagen, J. Shimshoni, M. Bialer
- Chemistry, Medicine
- Biochemical pharmacology
- 15 May 2005
The tumor cells toxicity of the antiepileptic drug valproic acid (VPA) has been associated with the inhibition of histone deacetylases (HDACs). We have assessed, in comparison to VPA, the HDACs… Expand
Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms.
- A. Hoffman, D. Stepensky, E. Lavy, S. Eyal, E. Klausner, M. Friedman
- Medicine
- International journal of pharmaceutics
- 11 June 2004
Controlled release gastroretentive dosage forms (CR-GRDF) enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the bioavailability of… Expand
Drug Interactions at the Human Placenta: What is the Evidence?
- Miriam Rubinchik-Stern, S. Eyal
- Medicine
- Front. Pharmacol.
- 1 May 2012
Pregnant women (and their fetuses) are treated with a significant number of prescription and non-prescription medications. Interactions among those drugs may affect their efficacy and toxicity in… Expand