• Publications
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Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification
Cardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells, thought to arise from distinct embryonic precursors. We use genetic fate-mapping studies to document thatExpand
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Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms ofExpand
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Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.
Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are keyExpand
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Nkx2-5 Pathways and Congenital Heart Disease Loss of Ventricular Myocyte Lineage Specification Leads to Progressive Cardiomyopathy and Complete Heart Block
Human mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unknown mechanisms. To define these pathways, we generated mice with a ventricular-restricted knockout ofExpand
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Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.
Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1Expand
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Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl4) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts.Expand
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Distinct origins and genetic programs of head muscle satellite cells.
Adult skeletal muscle possesses a remarkable regenerative capacity, due to the presence of satellite cells, adult muscle stem cells. We used fate-mapping techniques in avian and mouse models to showExpand
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Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy
  • Qiang Zhou, Po-Hsien Chu, +6 authors J. Chen
  • Biology, Medicine
  • The Journal of cell biology
  • 12 November 2001
Cypher is a member of a recently emerging family of proteins containing a PDZ domain at their NH2 terminus and one or three LIM domains at their COOH terminus. Cypher knockout mice display a severeExpand
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A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
We used conditional knockout strategies in mice to determine the developmental events and gene expression program regulated by the LIM-homeodomain factor Islet1 in developing sensory neurons. EarlyExpand
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T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
Mutations in T-box genes are the cause of several congenital diseases and are implicated in cancer. Tbx20-null mice exhibit severely hypoplastic hearts and express Tbx2, which is normally restrictedExpand
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