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Breakdown of Cortical Effective Connectivity During Sleep
TLDR
The fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity, as measured by transcranial magnetic stimulation and high-density electroencephalography. Expand
Cortical Firing and Sleep Homeostasis
TLDR
It is found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states, and changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Expand
A direct demonstration of cortical LTP in humans: A combined TMS/EEG study
TLDR
A new approach based on combined rTMS/high-density electroencephalography (hd-EEG) to obtain direct, noninvasive evidence for LTP in humans, which provides a direct demonstration in humans of LTP induced by rT MS. Expand
Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans.
TLDR
In the human EEG, the decline of SWA during sleep is accompanied by changes in slow-wave parameters that were predicted by a computer model simulating a homeostatic reduction of cortical synaptic strength. Expand
Triggering sleep slow waves by transcranial magnetic stimulation
TLDR
TMS triggering of slow waves reveals intrinsic bistability in thalamocortical networks during non-rapid eye movement sleep and leads to a deepening of sleep and to an increase in EEG slow-wave activity, which is thought to play a role in brain restoration and memory consolidation. Expand
Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves.
TLDR
Experimental results from rat cortical depth recordings and human high-density EEG show similar changes in slow-wave parameters with decreasing SWA, suggesting that the underlying mechanism may indeed be a net decrease in synaptic strength. Expand
Modeling the effects of transcranial magnetic stimulation on cortical circuits.
TLDR
A detailed model of a portion of the thalamocortical system is constructed and the effects of the simulated delivery of a TMS pulse are examined, providing a detailed, self-consistent account of the neural and synaptic activities evoked by TMS within prototypical cortical circuits. Expand
TMS-Induced Cortical Potentiation during Wakefulness Locally Increases Slow Wave Activity during Sleep
TLDR
These results provide direct evidence for a link between plastic changes and the local regulation of sleep need, and the magnitude of potentiation during wakefulness predicts the local increase in SWA during sleep. Expand
Measures of Cortical Plasticity after Transcranial Paired Associative Stimulation Predict Changes in Electroencephalogram Slow-Wave Activity during Subsequent Sleep
TLDR
It is suggested that changes in cortical excitability in opposite directions lead to corresponding changes in local sleep regulation, as reflected by SWA, providing evidence for a tight relationship between cortical plasticity and sleep intensity. Expand
Sleep and synaptic renormalization: a computational study.
TLDR
A large-scale model of the corticothalamic system equipped with a spike-timing dependent learning rule is used to demonstrate a net increase in synaptic strength in the waking mode associated with an increase in neuronal firing rates and synchrony and an exponential, self-limiting renormalization of synaptic strength during sleep. Expand
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