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Contaminated heparin associated with adverse clinical events and activation of the contact system.
TLDR
An assay to assess the amidolytic activity of kallikrein can supplement analytic tests to protect the heparin supply chain by screening for OSCS and other highly sulfated polysaccharide contaminants of hepar in that can activate the contact system.
Newcastle Disease Virus Exerts Oncolysis by both Intrinsic and Extrinsic Caspase-Dependent Pathways of Cell Death
TLDR
It is demonstrated that genetically modified, recombinant NDV strains are cytotoxic to human tumor cell lines of ecto-, endo-, and mesodermal origin and that recombinantNDV could be developed as a cancer virotherapy agent, either alone or in combination with therapeutic transgenes.
The Hemagglutinin-Neuraminidase Protein of Newcastle Disease Virus Determines Tropism and Virulence
TLDR
The chimeric viruses with reciprocal HN proteins either gained or lost virulence, as determined by a standard intracerebral pathogenicity index test of chickens and by the mean death time in chicken embryos, indicating that virulence is a function of the amino acid differences in the HN protein.
Relationship between Humidity and Influenza A Viability in Droplets and Implications for Influenza’s Seasonality
TLDR
Results in human mucus could help explain influenza’s seasonality in different regions and resolve conflicting findings in the literature on the relationship between IAV viability in aerosols and humidity.
Concentrations and size distributions of airborne influenza A viruses measured indoors at a health centre, a day-care centre and on aeroplanes
The relative importance of the aerosol transmission route for influenza remains contentious. To determine the potential for influenza to spread via the aerosol route, we measured the size
A Recombinant Newcastle Disease Virus (NDV) Expressing VP2 Protein of Infectious Bursal Disease Virus (IBDV) Protects against NDV and IBDV
TLDR
Results indicate that the recombinant NDV can be used as a vaccine vector for other avian pathogens and induced higher levels of antibody responses against both NDV and IBDV and conferred complete protection against both viruses.
Detection of a New Mycobacterium Species in Wild Striped Bass in the Chesapeake Bay
TLDR
The conclusion that the isolate obtained from fish showing skin ulcers and internal granulomas in various organs probably represents a new mycobacterial species is supported.
TGF-β–induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops
TLDR
Experimental and computational analyses identify multiple cell populations during the epithelial-to-mesenchymal transition and provide experimental confirmation for a model of cascading switches in phenotypes associated with TGF-β1–induced EMT of MCF10A cells that involves two double-negative feedback loops.
Recombinant Newcastle disease virus as a vaccine vector.
TLDR
This review will summarize the developments in using NDV as a vaccine vector and the potential of this approach in designing next generation vaccines for veterinary use.
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