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Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems.
GH and IGF-I and -II were first identified by their endocrine activity. Specifically, IGF-I was found to mediate the linear growth-promoting actions of GH. It is now evident that these two growthExpand
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Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides
Epidermal hyperplasia is a key feature of the common skin disorder psoriasis. Stimulation of epidermal keratinocytes by insulin-like growth factor I (IGF-I) is essential for cell division, andExpand
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Insulin‐like growth factor binding protein‐3 (IGFBP‐3) localizes to and modulates proliferative epidermal keratinocytes in vivo
Background  The colocalization of insulin‐like growth factor binding protein‐3 (IGFBP‐3) and IGF‐I receptor (IGF‐IR) in the basal/germinative layer of the epidermis suggests a key role in modulatingExpand
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Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment.
BACKGROUND Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH orExpand
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Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye.
PURPOSE To localize mRNAs for insulin-like growth factor (IGF)-I, IGF-I receptor (IGF-IR), and IGF binding protein (BP)-1 to IGFBP-6 in the rat eye. METHODS cDNA sequences for IGF-I, IGF-IR, andExpand
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Localization of messenger ribonucleic acid for insulin-like growth factor-binding proteins in human skin by in situ hybridization.
The role of the insulin-like growth factors (IGFs) in human skin physiology has been increasingly recognized, although relatively little is known about the cell types involved or the cellularExpand
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Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA.
Although GH plays a key role in postnatal growth, prenatal growth is thought to be GH independent. However, recent data has shown GH receptor/binding protein (GHR/BP) to be present in rat fetalExpand
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Localization of the Insulin-like Growth Factor System in a Rat Model of Heart Failure Induced by Myocardial Infarction
Although cardiac effects of growth hormone (GH) and insulin-like growth factor (IGF)-I have been reported in experimental models of heart failure and in human dilated cardiomyopathy, the IGF systemExpand
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Expression of insulin-like growth factor binding protein-3 (IGFBP-3) in the psoriatic lesion.
Epidermal hyper-proliferation is a key feature of psoriasis, and a role for IGF-I in this process has previously been proposed. Herein we investigated the expression of IGF binding proteins in theExpand
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Identification of growth hormone receptors on human growth plate chondrocytes
The mechanisms of action of growth hormone (GH) in mammals, including man, have been unclear until very recently. The original somatomedin hypothesis of Salmon and Daughaday (1) proposed that theExpand
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