Prediction of pathological stage and clinical outcome in prostate cancer: an improved pre-operative model incorporating biopsy-determined intraductal carcinoma.
The model which best predicted pathological stage and clinical outcome involved first identifying those cancers with IDC-P as having the poorest outcome, and thus derive an improved predictive model to aid the decision to initiate potentially curative therapy in localized prostate cancer.
Monoclonal Antibody Tkh2 To The Cancer‐Associated Epitope Sialosyl Tn Shows Cross‐Reactivity With Variants Of Normal Colorectal Goblet Cell Mucin
- J. Jass, L. Allison, S. Edgar
- BiologyPathology (Sydney)
The reactivity of TKH2 for colorectal cancer mucin can be readily explained by the loss of sialic acid O‐acetyl substituents and not necessarily by incomplete synthesis of mucin‐type carbohydrate chains.
Characterization of cytoplasmic secretory granules (PSG), in prostatic epithelium and their transformation-induced loss in dysplasia and adenocarcinoma.
- R. Cohen, J. McNeal, S. Edgar, T. Robertson, H. Dawkins
- Medicine, BiologyHuman Pathology
- 1 December 1998
Monocyte esterase deficiency in malignant neoplasia.
- G. Markey, J. McCormick, M. Mccaigue
- MedicineJournal of Clinical Pathology
- 1 April 1990
It is suggested that the reason for the increased prevalence of the anomaly in these disorders might be that the diminution of esterase activity has a role in their development.
Expression of myelin basic protein mRNA and polypeptides in mouse oligodendrocytes in culture: differential regulation by genetic and epigenetic factors.
- E. Barbarese, C. Barry, C. D'Occhio, S. Edgar, A. Akowitz, J. Carson
- BiologyBrain Research
- 1 April 1988
Unicryptal Loss Of Heterozygosity In Hereditary Non‐Polyposis Colorectal Cancer
The rate of background mutational activity in the normal colorectal mucosa of subjects with HNPCC was documented and supports the view that the mutational effects of the H NPCC gene occur selectively within adenomatous epithelium and serve to accelerate the adenoma‐carcinoma sequence.
Prostatic adenocarcinoma labelled with a monoclonal antibody and polyclonal serum: a quantitative assessment.
- E. Gray, L. J. Allison, S. Edgar, E. Robinson, R. Cohen
- Biology, MedicineBritish Journal of Urology
- 1 July 1996
The loss of PSA expression in some poorly differentiated cancers may represent the loss of specific epitopes rather than loss of the entire protein.
Monocyte esterase deficiency in gastrointestinal cancer.
There is a strong degree of association between monocyte esterase deficiency and gastrointestinal carcinoma and further evidence must be sought to prove that the deficiency precedes the disease and therefore may predispose to it, or at least may identify subjects with such a predisposition.
Co-delivery of indoleamine 2,3-dioxygenase prevents loss of expression of an antigenic transgene in dystrophic mouse muscles
- D. Sharma, R. Al-khalidi, D. Górecki
- BiologyGene Therapy
- 22 December 2016
It is indicated that co-expression of genes encoding immunomodulatory enzymes controlling kynurenine pathways provide a viable strategy for preventing loss of transgenes targeted into dystrophic muscles with pre-existing inflammation.