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A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for typeExpand
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations betweenExpand
European guidelines on cardiovascular disease and prevention in clinical practice.
Authors/Task Force Members: Massimo F. Piepoli* (Chairperson) (Italy), Arno W. Hoes* (Co-Chairperson) (The Netherlands), Stefan Agewall (Norway)1, Christian Albus (Germany)9, Carlos BrotonsExpand
European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012)
Atherosclerotic cardiovascular disease (CVD) is a chronic disorder developing insidiously thoughout life and usually progressing to an advanced stage by the time symptoms occur. It remains the majorExpand
Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials.
PURPOSE To review the effectiveness of exercise-based cardiac rehabilitation in patients with coronary heart disease. METHODS A systematic review and meta-analysis of randomized controlled trialsExpand
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fastingExpand
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprisingExpand
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis ofExpand
European guidelines on cardiovascular disease prevention in clinical practice: executive summary.
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) : the Fifth Joint Task Force of the European Society of Cardiology and Other Societies on CardiovascularExpand
European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular
European guidelines on cardiovascular disease prevention in clinical practice: Executive summary Authors/Task Force Members: Ian Graham (Chairperson) ∗,1, Dan Atar1, Oslo (Norway), KnutExpand
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