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A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
European guidelines on cardiovascular disease and prevention in clinical practice.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials.
European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012)
- J. Perk, G. Backer, Developed with the special contribution of the European Asso Rehabilitation
- MedicineInternational Journal of Behavioral Medicine
- 1 July 2012
Atherosclerotic cardiovascular disease is a chronic disorder developing insidiously thoughout life and usually progressing to an advanced stage by the time symptoms occur, thereby remaining the leading somatic cause of loss of productivity.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising…
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
Mendelian randomization provides new opportunities to test causality and demonstrates how investment in the human genome project may contribute to understanding and preventing the adverse effects on human health of modifiable exposures.
Exercise-based cardiac rehabilitation for coronary heart disease.
Exercise-based cardiac rehabilitation is effective in reducing total and cardiovascular mortality and hospital admissions but not total MI or revascularisation (CABG or PTCA); despite inclusion of more recent trials, the population studied in this review is still predominantly male, middle aged and low risk.