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Possible Mechanism Underlying the Effect of Semax on the Formation of Indomethacin-Induced Ulcers in Rats
TLDR
Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers, probably related to improvement of blood flow in the gastric wall disturbed by indometHacin. Expand
Effect of semax on homeostasis of gastric mucosa in albino rats
The ACTH4–7 analogue Semax administered intrapeitoneally in a dose of 50 μg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosaExpand
[Pancreatic hormone amylin and integrity of the gastric mucosa].
TLDR
The protective antiulcerous properties of amyline reduce the action of aggressive agents on the gastric mucosa and stimulate protective ones and promote the maintenance of tissue homeostasis. Expand
Metabolism of PGP Peptide after Administration via Different Routes
TLDR
It is shown by HPLC that unmodified PGP is released into the blood after administration by all three routes and is detected in the plasma over 3-5 h, presumably determining (together with tripeptide) its pharmacological properties. Expand
[Homeostasis in the gastric mucosa and blood circulation. Part 1. Mechanisms of the adequate blood flow maintenance in the gastric mucosa].
TLDR
Nitric oxide and prostaglandines are the most important low molecular weight compounds that play the main role in the maintenance of the basal gastric mucosal blood flow and in the development of hyperemic responses to harmful agents. Expand
Secretory Activity of Mast Cell during Stress: Effect of Prolyl-Glycyl-Proline and Semax
TLDR
Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine and probably determines their antiulcer activity. Expand
Effect of Amylin on Mast Cell Secretion as a Possible Mechanism Increasing Gastric Mucosa Resistance
TLDR
Amylin-induced stabilization of activated mast cells probably underlies its protective effects during ulceration and abolished the activating effects of acetylcholine and bradykinin on mast cell degranulation in in vitro experiments. Expand
Antiulcer Effects of the Tripeptide PGP and Its Possible Metabolites (PG, GP, Glycine, and Proline) in Different Models of Ulcer Induction in Rats
TLDR
The results of this study indicate that the antiulcer activity of PGP may be related to the effect of this tripeptide itself and to proteolysis of P GP to dipeptides and amino acids as well. Expand
[Correction of the stomach blood flow as a mechanism of anti-ulcer effects of short proline-containing peptides].
TLDR
The mucosal blood flow correction seems to be one of the possible mechanisms of the PGP and PG antiulcer effect and appears to be realised through a change in the CNS activity. Expand
[Semax and some glyproline peptides accelerate the healing of acetic ulcers in rats].
TLDR
The dynamics of structural changes in the place of ulcer formation investigated with the use of cytohistological control demonstrated that their anti-ulcer effects can be related to their ability to accelerate ulcer clarification from necrotic tissues and to activate the process of cicatrisation and epithelization. Expand
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