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Global profiling of dynamic protein palmitoylation
The reversible thioester linkage of palmitic acid on cysteines, known as protein S-palmitoylation, facilitates the membrane association and proper subcellular localization of proteins. Here we reportExpand
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Proteome-wide Mapping of Cholesterol-Interacting Proteins in Mammalian Cells
Cholesterol is an essential structural component of cellular membranes and serves as a precursor for several classes of signaling molecules. Cholesterol exerts its effects and is, itself, regulatedExpand
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Sulfation patterns of glycosaminoglycans encode molecular recognition and activity
Although glycosaminoglycans contribute to diverse physiological processes1,2,3,4, an understanding of their molecular mechanisms has been hampered by the inability to access homogeneousExpand
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Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis*
Background: Sulfolipid-1 (SL-1) is a Mycobacterium tuberculosis outer membrane lipid whose biosynthesis is not fully understood. Results: Chp1 catalyzes two acyl transfer reactions to form SL-1. SapExpand
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A sulfated carbohydrate epitope inhibits axon regeneration after injury
Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hamperedExpand
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Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury. Their diverse biological activities are derivedExpand
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Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays
We report the first example of synthetic chondroitin sulfate (CS) microarrays to rapidly identify glycosaminoglycan−protein interactions and probe the specificity of proteins for distinct sulfationExpand
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Activation of phospholipase C pathways by a synthetic chondroitin sulfate‐E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons
In dopaminergic neurons, chondroitin sulfate (CS) proteoglycans play important roles in neuronal development and regeneration. However, due to the complexity and heterogeneity of CS, the preciseExpand
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Synthesis of 11-cis-locked bicyclo[5.1.0]octanyl retinal and an enantioselective binding to bovine opsin.
Both enantiomers of 13-(E) and 13-(Z) isomers of 11-cis-locked bicyclo[5.1.0]octanyl retinal were prepared by an improved synthesis and incubated with bovine opsin. The synthesis also establishes theExpand
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A chondroitin sulfate small molecule that stimulates neuronal growth.
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of aExpand
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