S. E. Truesdell

Publications9
h-index7
Citations761
Highly Influential Citations18
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Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein
TLDR
A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced and was a potent inhibitor of IL-1 induced corticosterone production in vivo.
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Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors.
TLDR
Results suggest that thiadiazole urea heterocycles which incorporate a substituted phenylalanine can provide selective inhibitors of stromelysin.
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Isolation and structure of antibiotic U-68,204, a new thiolactone.
TLDR
A new thiolactone-containing antibiotic U-68,204 was found to be produced by a soil actinomycete identified as StreptomycesThiolactonus UC 8478 (NRRL 15,439) and the antibiotic was identified as the 10-carboxamide of thiotetromycin.
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In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608
U-78608, a new monocarbam antibiotic, was evaluated for in vitro activity against 312 clinical isolates of aerobic and anaerobic bacteria and subjected to several in vitro biochemical tests…
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Purification and characterization of interleukin 1 receptor level antagonist proteins from THP-1 cells.
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Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus.
TLDR
Results suggest that the somewhat lower MICs detected with cefmetazole for MRSA may be a consequence of the interaction of the antibiotic with PBP2'; its affinity for these PBPs is lower than that of cefazolin.
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Production, isolation, and identification of dihydroepiepoformin as an IL-1 receptor antagonistic component in Penicillium patulum.
TLDR
The separation of DHEEF from EEF was achieved by using preparative HPLC(Waters Prep 3000) procedures and the peak fraction was estimated to be 90% pure by measuring the NMRsignal intensities.
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Arginomycin: production, isolation, characterization and structure.
TLDR
Arginomycin, C18H28N8O5, which inhibits the growth of Gram-positive bacteria and fungi in vitro, is structurally related to blasticidin S and found to be relatively non-toxic.
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Monazomycin B, a new macrolide antibiotic of the monazomycin family.
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