Attempts to immunize sheep against Haemonchus contortus using a cocktail of recombinant proteases derived from the protective antigen, H‐gal‐GP
- É. Cachat, G. Newlands, S. E. Ekoja, H. McAllister, W. Smith
- BiologyParasite immunology (Print)
- 1 June 2010
High levels of serum antibodies that recognized H‐gal‐GP were detected in both the native antigen and recombinantly expressed cocktail‐immunized groups by the time of challenge, but protective immunity was only observed in the group immunized with native H‐Gal‐GP.
Antibodies from sheep immunized against Haemonchus contortus with H‐gal‐GP inhibit the haemoglobinase activity of this protease complex
Results support the theory that the mechanism of protection in sheep vaccinated with H‐gal‐GP is by specific antibodies impairing the parasites ability to digest its blood meal.