• Publications
  • Influence
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.
TLDR
A model is proposed in which a ligand-dependent conformational change in a heme protein accounts for the mechanism by which hypoxia as well as cobalt and nickel stimulate the production of Epo. Expand
Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death.
TLDR
Glutathione levels increase during HSC activation and protect against ROS-induced necrosis, whereas hydrogen peroxide-detoxifying enzymes protect against apoptotic cell death. Expand
Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death
Background: In chronic liver injury, hepatic stellate cells (HSCs) proliferate and produce excessive amounts of connective tissue causing liver fibrosis and cirrhosis. Oxidative stress has beenExpand
Multidrug resistance–associated proteins are crucial for the viability of activated rat hepatic stellate cells
TLDR
Mrp‐dependent export of endogenous metabolites is important for the survival of activated HSCs in chronic liver diseases and Mrp‐type transporters are required for the viability of activatedHSCs. Expand
Resistance of activated stellate cells to cell death in liver fibrosis: mechanisms and targets for intervention
TLDR
Mrp-dependent export of endogenous metabolites is essential for the survival of activated HSCs in chronic liver diseases and MDR-associated proteins are crucial for the viability of rat aHSCs. Expand
Oxygen sensing and erythropoietin gene regulation in a human hepatoma cell line.
...
1
2
...