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Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.
A model is proposed in which a ligand-dependent conformational change in a heme protein accounts for the mechanism by which hypoxia as well as cobalt and nickel stimulate the production of Epo. Expand
Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death.
- S. Dunning, Atta Ur Rehman, +7 authors H. Moshage
- Chemistry, Medicine
- Biochimica et biophysica acta
- 1 December 2013
Glutathione levels increase during HSC activation and protect against ROS-induced necrosis, whereas hydrogen peroxide-detoxifying enzymes protect against apoptotic cell death. Expand
Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death
- S. Dunning, R. Hannivoort, J. F. de Boer, M. Buist-Homan, K. Faber, H. Moshage
- Chemistry, Medicine
- Liver international : official journal of the…
- 1 July 2009
Background: In chronic liver injury, hepatic stellate cells (HSCs) proliferate and produce excessive amounts of connective tissue causing liver fibrosis and cirrhosis. Oxidative stress has been… Expand
Multidrug resistance–associated proteins are crucial for the viability of activated rat hepatic stellate cells
Mrp‐dependent export of endogenous metabolites is important for the survival of activated HSCs in chronic liver diseases and Mrp‐type transporters are required for the viability of activatedHSCs. Expand
Reactive oxygen species do not directly induce proliferation of activated hepatic stellate cells
Resistance of activated stellate cells to cell death in liver fibrosis: mechanisms and targets for intervention
- S. Dunning
Mrp-dependent export of endogenous metabolites is essential for the survival of activated HSCs in chronic liver diseases and MDR-associated proteins are crucial for the viability of rat aHSCs. Expand
Glutathione, but not catalase is important in protection of hepatic stellate cells against oxidative stress
- S. Dunning, R. Hannivoort, L. Rosa, M. Buist-Homan, K. Faber, H. Moshage
- Medicine, Biology
- 1 October 2007
RIBAVIRIN INHIBITS PROLIFERATION OF ACTIVATED RAT HEPATIC STELLATE CELLS IN VITRO AND IN A NON-VIRAL IN VIVO RAT MODEL FOR LIVER FIBROSIS
- R. Hannivoort, S. Dunning, M. Buist-Homan, Kyrion van Pelt, K. Faber, H. Moshage
- 1 October 2008
Different inducers of oxidative stress have divergent effects on survival and proliferation of activated rat hepatic stellate cells
Oxygen sensing and erythropoietin gene regulation in a human hepatoma cell line.