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Dominant and diet-responsive groups of bacteria within the human colonic microbiota
Time courses obtained by targeted qPCR revealed that ‘blooms’ in specific bacterial groups occurred rapidly after a dietary change, and these were rapidly reversed by the subsequent diet.
The role of the gut microbiota in nutrition and health
- H. Flint, K. Scott, P. Louis, S. Duncan
- MedicineNature Reviews Gastroenterology &Hepatology
- 1 October 2012
The complex interplay between the gut microbiota, diet and health is considered and better definition of those dominant commensal bacteria, community profiles and system characteristics that produce stable gut communities beneficial to health is important.
The microbiology of butyrate formation in the human colon.
A better understanding of the microbial ecology of colonic butyrate-producing bacteria will help to explain the influence of diet uponbutyrate supply, and to suggest new approaches for optimising microbial activity in the large intestine.
Reduced Dietary Intake of Carbohydrates by Obese Subjects Results in Decreased Concentrations of Butyrate and Butyrate-Producing Bacteria in Feces
- S. Duncan, A. Belenguer, G. Holtrop, A. Johnstone, H. Flint, G. Lobley
- Biology, MedicineApplied and Environmental Microbiology
- 22 December 2006
ABSTRACT Weight loss diets for humans that are based on a high intake of protein but low intake of fermentable carbohydrate may alter microbial activity and bacterial populations in the large…
Microbial degradation of complex carbohydrates in the gut
The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.
Phylogenetic Relationships of Butyrate-Producing Bacteria from the Human Gut
Fifty percent of the butyrate-producing isolates were net acetate consumers during growth, suggesting that they employ the butyryl coenzyme A-acetyl coen enzyme A transferase pathway forbutyrate production.
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Bacteria able to utilize lactate and produce butyrate were identified among isolates obtained from 10−8 dilutions of fecal samples from five different subjects, and the abundance of E. hallii in particular in the colonic ecosystem suggests that these bacteria play important roles in preventing lactate accumulation.
Links between diet, gut microbiota composition and gut metabolism
Predicting the impact of diet upon such a complex and interactive system as the human gut microbiota not only requires more information on the component groups involved but, increasingly, the integration of such information through modelling approaches.
pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon
- A. Walker, S. Duncan, E. C. McWilliam Leitch, Matthew W Child, H. Flint
- BiologyApplied and Environmental Microbiology
- 1 July 2005
It is suggested that a lowering of pH resulting from substrate fermentation in the colon may boost butyrate production and populations ofbutyrate-producing bacteria, while at the same time curtailing the growth of Bacteroides spp.
The role of pH in determining the species composition of the human colonic microbiota.
Inhibition of the growth of a major group of gram-negative bacteria at mildly acidic pH apparently creates niches that can be exploited by more low pH-tolerant microorganisms.