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Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis
Graphical Abstract Highlights d Combined SGA technology, high throughput imaging, and automated analysis using SVM d Quantified in vivo abundance and localization of 4,100 GFP fusion proteins dExpand
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Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer
Significance Chromosome instability (CIN) is well established as an enabling characteristic of cancer that contributes to cancer initiation and progression. Here, we identify 245 genes whoseExpand
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Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.
Proteomics has proved invaluable in generating large-scale quantitative data; however, the development of systems approaches for examining the proteome in vivo has lagged behind. To evaluate proteinExpand
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Exploring the Yeast Acetylome Using Functional Genomics
Lysine acetylation is a dynamic posttranslational modification with a well-defined role in regulating histones. The impact of acetylation on other cellular functions remains relativelyExpand
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The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast.
The budding yeast Saccharomyces cerevisiae has served as an excellent model system for studying highly conserved biological pathways including pathways involved in genome transmission andExpand
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Systematic over-expression screens for chromosome instability identify conserved dosage chromosome instability genes in yeast and human tumors
Somatic copy number amplifications (SCNAs) and gene over-expression are common features of many cancers. To determine the role of gene over-expression on genome stability, we performed functionalExpand
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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase
Mutations that cause genome instability are considered important predisposing events that contribute to initiation and progression of cancer. Genome instability arises either due to defects in genesExpand
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