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Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
TLDR
The superior potency of BAPTA compared to EGTA apparently results from the faster calcium-binding kinetics of B APTA and suggests that the calcium- binding molecule that triggers release binds calcium in considerably less than 200 microsec and is located very close to calcium channels. Expand
D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning
TLDR
D-serine may enhance a form of hippocampal NR2B-dependent LTD that contributes to spatial reversal learning, which could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors. Expand
Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory.
TLDR
The data indicate that exposure of mice to spatial enrichment alters the PKA dependence of LTP and enhances one type of hippocampus-dependent memory, and it is suggested that experience-dependent plasticity of the Pka dependence of hippocampal LTP may be important for regulating the efficacy of hippocamp-based memory. Expand
Imaging Spreading Depression and Associated Intracellular Calcium Waves in Brain Slices
TLDR
The results demonstrate that although there are calcium dynamics associated with SD, these increases are not necessary for the initiation or propagation of spreading depression. Expand
Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP‐dependent protein kinase
TLDR
The genetic and pharmacological experiments show that LTP induced by compressed patterns of stimulation does not require PKA activation, and altering the temporal spacing of synaptic stimulation per se critically modulates the PKA‐dependence of hippocampal LTP. Expand
Mutation I810N in the α3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
TLDR
The functional significance of the Na+,K+-ATPase α3 isoform in the control of epileptiform activity and seizure behavior is revealed and it is revealed that the epilepsy in Myk/+ mice and in vitro hyperexcitability could be prevented by delivery of additional copies of wild-type Na+K+. Expand
In vitro ischemia promotes calcium influx and intracellular calcium release in hippocampal astrocytes
  • S. Duffy, B. MacVicar
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 January 1996
TLDR
The absence of significant basal [Ca2+]i increases on isolated astrocytes indicates that ischemia-induced Ca2+ influx and internal release in astroCytes within slices depend on signals released from neurons (K+, neurotransmitters). Expand
GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes
TLDR
Data support the view that astrocytes, like neurons, express GABAA receptors and target subunit isoforms to distinct cellular localizations, and a GABA-evoked increase in [Ca2+]i could serve as a signal between GABAergic neurons and astroCytes. Expand
Homosynaptic facilitation of transmitter release in crayfish is not affected by mobile calcium chelators: implications for the residual ionized calcium hypothesis from electrophysiological and
TLDR
A reaction-diffusion model in 3D rectangular coordinates for Ca2+ diffusion in the presence of mobile and immobile buffers predicts that mobile calcium buffers with appropriate physical properties will attenuate facilitation and hasten its decay by removing residual calcium. Expand
Adrenergic calcium signaling in astrocyte networks within the hippocampal slice
  • S. Duffy, B. MacVicar
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 August 1995
TLDR
A primary role of NE release and alpha 1-adrenoceptor stimulation in neuron-astrocyte communication in the mature CNS is supported. Expand
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